Evidence map›Paper›PMID 29603493›Full record

ArticleCancer science2018

Long non-coding RNA-CTD-2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor.

Mozhi Wang, Mengshen Wang, Zhenning Wang, Xueting Yu, Yongxi Song, Chong Wang, Yujie Xu, Fengheng Wei, Yi Zhao, Yingying Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Noncoding RNAs, Vital Players in Breast Cancer Metastasis.Breast cancer (Dove Medical Press) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mozhi WangDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Mengshen WangDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Zhenning WangDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, China.ORCID http://orcid.org/0000-0003-0557-3097
Xueting YuDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yongxi SongDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, China.
Chong WangDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yujie XuDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Fengheng WeiDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yi ZhaoDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yingying XuDepartment of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.ORCID http://orcid.org/0000-0003-4924-9379
First Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non-coding RNA-CTD-2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC. Mechanistic investigation determined that lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBreast NeoplasmsCell LineCell Line, TumorCell MovementFemaleHumansLymphatic MetastasisMCF-7 CellsMice, Inbred BALB CMice, NudeMiddle AgedReceptors, OSM-LIFRNA InterferenceRNA, Long NoncodingReceptors, OSM-LIFRNA, Long Noncodingbreast cancerEMTLIFRlncRNAmetastasis

Identifiers

PMID29603493
PMCPMC5989867
OpenAlexW2794528969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.