ArticleThe European journal of neuroscience2019
A silent eligibility trace enables dopamine-dependent synaptic plasticity for reinforcement learning in the mouse striatum.
Article in The European journal of neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 102 citations in OpenAlex.
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.Biological cybernetics · 2026Article
- From Spontaneous Ignitions to Sensorimotor Cell Assemblies via Dopamine: A Spiking Neurocomputational Model of Infants' Hand Action Acquisition.Brain sciences · 2026Article
- Enhancement of calcium responses by KJournal of biosciences · 2026Article
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- Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.Research square · 2025Article
- Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.bioRxiv : the preprint server for biology · 2025Article
- Sequence termination cues drive habits via dopamine-mediated credit assignment.bioRxiv : the preprint server for biology · 2025Article
- Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates.Journal of neuroscience methods · 2025Article
- Noise Resilience of Successor and Predecessor Feature Algorithms in One- and Two-Dimensional Environments.Sensors (Basel, Switzerland) · 2025Article
- A minimal model of cognition based on oscillatory and current-based reinforcement processes.Journal of the Royal Society, Interface · 2025Article
- Dopamine builds and reveals reward-associated latent behavioral attractors.Nature communications · 2024Article
- Investigating Transfer Learning in Noisy Environments: A Study of Predecessor and Successor Features in Spatial Learning Using a T-Maze.Sensors (Basel, Switzerland) · 2024Article
- Astrocyte D1/D5 Dopamine Receptors Govern Non-Hebbian Long-Term Potentiation at Sensory Synapses onto Lamina I Spinoparabrachial Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Sensory Reinforced Corticostriatal Plasticity.Current neuropharmacology · 2024Article
- Using rodent data to elucidate dopaminergic mechanisms of ADHD: Implications for human personality.Personality neuroscience · 2024Review
- A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.Science advances · 2023Article
- The Dysfunctional Mechanisms Throwing Tics: Structural and Functional Changes in Tourette Syndrome.Behavioral sciences (Basel, Switzerland) · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine-dependent synaptic plasticity is a candidate mechanism for reinforcement learning. A silent eligibility trace - initiated by synaptic activity and transformed into synaptic strengthening by later action of dopamine - has been hypothesized to explain the retroactive effect of dopamine in reinforcing past behaviour. We tested this hypothesis by measuring time-dependent modulation of synaptic plasticity by dopamine in adult mouse striatum, using whole-cell recordings. Presynaptic activity followed by postsynaptic action potentials (pre-post) caused spike-timing-dependent long-term depression in D1-expressing neurons, but not in D2 neurons, and not if postsynaptic activity followed presynaptic activity. Subsequent experiments focused on D1 neurons. Applying a dopamine D1 receptor agonist during induction of pre-post plasticity caused long-term potentiation. This long-term potentiation was hidden by long-term depression occurring concurrently and was unmasked when long-term depression blocked an L-type calcium channel antagonist. Long-term potentiation was blocked by a Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.