ArticleJournal of clinical laboratory analysis2018
Age-specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite
Article in Journal of clinical laboratory analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
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- MOG IgG3-Subclass Antibodies in MOG-Associated Disease: Insights From a Pediatric Case With IgG1 Deficiency and Literature Review.Neurology(R) neuroimmunology & neuroinflammation · 2026Review
- Sequence variants influencing the regulation of serum IgG subclass levels.Nature communications · 2024Article
- Pediatric reference interval verification for 16 biochemical markers on the Alinity ci system in the CALIPER cohort of healthy children and adolescents.Clinical chemistry and laboratory medicine · 2023Article
- Circulating prolactin level in Juvenile Systemic Lupus Erythematosus and its correlation with disease activity: a case control study.Pediatric rheumatology online journal · 2023Article
- ERS International Congress 2022: highlights from the Thoracic Surgery and Lung Transplantation Assembly.ERJ open research · 2023Review
- IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders.Medical microbiology and immunology · 2023Article
- Commercialized kits to assess T-cell responses against SARS-CoV-2 S peptides. A pilot study in health care workers.Medicina clinica (English ed.) · 2022Article
- Commercialized kits to assess T-cell responses against SARS-CoV-2 S peptides. A pilot study in health care workers.Medicina clinica · 2022Article
- BCG Vaccine-Associated Complications in Patients with PTEN Hamartoma Tumor Syndrome.Journal of clinical immunology · 2021Article
- A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.Clinical & translational immunology · 2021Article
- Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population.Frontiers in immunology · 2020Review
- Classical pathway activity C3c, C4 and C1-inhibitor protein reference intervals determination in EDTA plasma.Biochemia medica · 2019Article
- Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management.Frontiers in immunology · 2019Article
- Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management.Respiratory research · 2018Review
- Age-specific pediatric reference ranges for immunoglobulins and complement proteins on the OptiliteJournal of clinical laboratory analysis · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMeasurement of immunoglobulins and complement proteins are frontline tests used in the assessment of immune system integrity, and reference values can vary with age. Their measurement provides an insight into the function of the innate and adaptive immune systems.
methodsWe generated pediatric reference ranges for IgG, IgA, IgM, IgD, the IgG and IgA subclasses, and C3 and C4 using the Optilite™ turbidimetric analyzer.
resultsThe concentrations of IgG, IgA, and IgD showed an increase with age, as expected, while IgM remained stable between the age groups. For the IgG subclasses, no significant differences were observed in IgG1 or IgG3, while IgG2 and IgG4 concentrations increased steadily with age. The concentration of IgG2 plateaued at 15-18 years, while IgG4 plateaued at 10-14 years. The trend of concentrations across all groups was IgG1 > IgG2 > IgG3 > IgG4. For both IgA1 and IgA2, concentrations increased significantly with age, plateauing at 15-18 years. The median IgA1 concentration was greater than IgA2 across all groups. There was a good correlation between the total IgG or IgA concentration and summation of their subclasses (R
conclusionWe have generated age-specific reference ranges in healthy children for C3, C4, IgG, IgA, IgM, IgD and the IgG and IgA subclasses using the Optilite
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.