Evidence map›Paper›PMID 29603116›Full record

ArticleCardiovascular toxicology2018

Methylene Blue Counteracts H

Joseph Y Cheung, JuFang Wang, Xue-Qian Zhang, Jianliang Song, John M Davidyock, Fabian Jana Prado, Santhanam Shanmughapriya, Alison M Worth, Muniswamy Madesh, Annick Judenherc-Haouzi and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. The NADPH oxidase inhibitor diphenyleneiodonium suppresses CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  2. Article
  3. Article
  4. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019
    Review
  5. Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Joseph Y CheungCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA. joseph.cheung@tuhs.temple.edu.ORCID 0000-0002-8024-9177
JuFang WangCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Xue-Qian ZhangCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Jianliang SongCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
John M DavidyockDepartment of Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, PA, 19140, USA.
Fabian Jana PradoCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Santhanam ShanmughapriyaCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Alison M WorthCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Muniswamy MadeshCenter of Translational Medicine, Lewis Katz School of Medicine of Temple University, 3500 N. Broad Street, MERB 958, Philadelphia, PA, 19140, USA.
Annick Judenherc-HaouziHeart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Philippe HaouziDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Temple University · USPennsylvania State University · US

Funding

Involvement of BAG3 in HIV-1 induced cardiomyopathyR01HL123093 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y, FELDMAN, ARTHUR M · 2014 to 2018
$3.7M
Methylene blue as an antidote against hydrogen sulfide intoxicationU01NS097162 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAOUZI, PHILIPPE A · 2016 to 2018
$2.2M
Trpm2: A novel target in Onco-cardiologyR01HL137426 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y · 2017 to 2020
$2.2M
Methylene Blue, A Novel Treatment of H2S Poisoning-induced Brain InjuryR21NS090017 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAOUZI, PHILIPPE A · 2014 to 2015
$802k
Effects of acute administration of the Phenothiazinium Chromophore Methylene blue during life threatening cyanide intoxicationR21NS098991 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAOUZI, PHILIPPE A · 2016 to 2017
$442k
NHLBI NIH HHS R01 HL123093NHLBI NIH HHS R01 HL137426NINDS NIH HHS R21 NS090017NINDS NIH HHS R21 NS098991NINDS NIH HHS U01 NS097162
6 · The paper itself

Abstract

We have previously demonstrated that methylene blue (MB) counteracts the effects of hydrogen sulfide (H

Indexed as

Action PotentialsAdenosine TriphosphateAnimalsArrhythmias, CardiacCalcium Channels, L-TypeCalcium SignalingEnergy MetabolismHeart RateHydrogen SulfideIon ChannelsMembrane Potential, MitochondrialMethylene BlueMiceMitochondria, HeartMyocardial ContractionMyocytes, CardiacAdenosine TriphosphateCalcium Channels, L-TypeHydrogen SulfideIon ChannelsMethylene BluePotassium Channels, Voltage-GatedSodium-Calcium ExchangerArrhythmogenesisIon currentsPatch clampSulfide toxicity

Identifiers

PMID29603116
PMCPMC6126975
OpenAlexW2795119116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.