ArticleMycopathologia2018
Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells.
Article in Mycopathologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 57 citations in OpenAlex.
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- D-lactic acid inhibits Candida albicans associated with vulvovaginal candidiasis: in vitro and in vivo effects and underlying mechanisms.BMC microbiology · 2025Article
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- Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS).Applied microbiology and biotechnology · 2024Article
- Aggregation and adhesion ability of various probiotic strains andJournal of dental sciences · 2024Article
- Multifactorial inhibition of Candida albicans by combinations of lactobacilli and probiotic Saccharomyces cerevisiae CNCM I-3856.Scientific reports · 2024Article
- Impact of interkingdom microbial interactions in the vaginal tract.PLoS pathogens · 2024Article
- Identification of Flo11-like Adhesin inMicroorganisms · 2024Article
- Protective Properties of S-layer Protein 2 fromBiomolecules · 2023Article
- The Vaginal Microbiota of Pregnant Women Varies with Gestational Age, Maternal Age, and Parity.Microbiology spectrum · 2023Article
- Antagonistic Interactions of Lactic Acid Bacteria from Human Oral Microbiome againstMicroorganisms · 2023Article
- Anti-Microorganisms · 2023Article
- Acetate modulates the inhibitory effect ofMicrobial cell (Graz, Austria) · 2023Article
- Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2023Article
- Intestinal bacteria-a powerful weapon for fungal infections treatment.Frontiers in cellular and infection microbiology · 2023Review
- Inhibitory effects of vaginalFrontiers in cellular and infection microbiology · 2023Article
- Inhibitory effect of lactobacilli supernatants on biofilm and filamentation ofFrontiers in microbiology · 2023Article
- Lactobacilli extracellular vesicles: potential postbiotics to support the vaginal microbiota homeostasis.Microbial cell factories · 2022Article
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVulvovaginal candidiasis (VVC) is a common superficial infection of the vaginal mucous membranes caused by the fungus Candida albicans. The aim of this study was to assess the mechanisms underlying the inhibitory effects of the culture supernatants of Lactobacillus gasseri and L. crispatus, the predominant microbiota in Asian healthy women, on C. albicans biofilm formation. The inhibition of C. albicans adhesion to HeLa cells by Lactobacillus culture supernatant was also investigated.
methodsCandida albicans biofilm was formed on polystyrene flat-bottomed 96-well plates, and the inhibitory effects on the initial colonization and maturation phases were determined using the XTT reduction assay. The expression levels of biofilm formation-associated genes (HWP1, ECE1, ALS3, BCR1, EFG1, TEC1, and CPH1) were determined by reverse transcription quantitative polymerase chain reaction. The inhibition of C. albicans adhesion to HeLa cells by Lactobacillus culture supernatant was evaluated by enumerating viable C. albicans cells.
resultsThe culture supernatants of both Lactobacillus species inhibited the initial colonization and maturation of C. albicans biofilm. The expression levels of all biofilm formation-related genes were downregulated in the presence of Lactobacillus culture supernatant. The culture supernatant also inhibited C. albicans adhesion to HeLa cells.
conclusionThe culture supernatants of L. gasseri and L. crispatus inhibited C. albicans biofilm formation by downregulating biofilm formation-related genes and C. albicans adhesion to HeLa cells. These findings support the notion that Lactobacillus metabolites may be useful alternatives to antifungal drugs for the management of VVC.
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