Evidence map›Paper›PMID 29602904›Full record

ArticleThe Journal of biological chemistry2018

A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.

Subrata Debnath, Dalibor Kosek, Harichandra D Tagad, Stewart R Durell, Daniel H Appella, Roderico Acevedo, Alexander Grishaev, Fred Dyda, Ettore Appella, Sharlyn J Mazur

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. PHLPP is neither a Phosphatase nor a Tumor Suppressor.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Article
  4. PPM1B utilizes a trinuclear metal architecture for phosphatase activity.bioRxiv : the preprint server for biology · 2026
    Article
  5. PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A comprehensive overview of PPM1A: From structure to disease.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Subrata DebnathLaboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland 20892.
Dalibor KosekLaboratories of Molecular Biology, Bethesda, Maryland 20892.
Harichandra D TagadLaboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland 20892.
Stewart R DurellLaboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland 20892.
Daniel H AppellaBioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
Roderico AcevedoInstitute for Bioscience and Biotechnology Research, Rockville, Maryland 20850.
Alexander GrishaevInstitute for Bioscience and Biotechnology Research, Rockville, Maryland 20850; National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
Fred DydaLaboratories of Molecular Biology, Bethesda, Maryland 20892.
Ettore AppellaLaboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland 20892.
Sharlyn J MazurLaboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland 20892. Electronic address: mazurs@mail.nih.gov.
Center for Cancer Research · USInstitute for Bioscience and Biotechnology ResearchNational Institute of Standards and Technology · USNational Institutes of Health · US

Funding

Chemically Modified Peptide Nucleic AcidsZIADK031143 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2009 to 2025
$13.9M
Regulation and Function of WIP1 Phosphatase and its Role in Tumor CellsZIABC011197 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APPELLA, ETTORE · 2009 to 2025
$11.5M
Small Molecular Inactivators of HIVZIADK075135 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2016 to 2025
$7.2M
Inhibitor Development Against the Wip1 PhosphataseZIABC011379 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DURELL, STEWART · 2011 to 2022
$1.3M
Structure and Function of Metal-Dependent Protein PhosphatasesZIADK075148 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DYDA, FREDERICK · 2018 to 2021
$406k
6 · The paper itself

Abstract

Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg

Indexed as

Amino Acid SequenceBinding SitesCatalytic DomainCrystallography, X-RayHumansMetalsModels, MolecularMutagenesis, Site-DirectedMutationPhosphopeptidesProtein ConformationProtein Phosphatase 2CSequence HomologySubstrate SpecificityMetalsPhosphopeptidesPPM1A protein, humanProtein Phosphatase 2Ccyclic peptideenzyme structuremetalloenzymemolecular dynamicsprotein serine/threonine phosphatase (PSP)signal transductionsmall-angle X-ray scattering (SAXS)X-ray crystallography

Identifiers

PMID29602904
PMCPMC5971455
OpenAlexW2795289779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.