Evidence map›Paper›PMID 29602886›Full record

ArticleBMJ case reports2018

Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis.

Mark Louis Siefring, Doanh Lu, J Christopher States, Minh Van Hoang

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark Louis SiefringDepartment of Dermatology, Stamford Skin Centre, Ho Chi Minh City, Vietnam.
Doanh LuDepartment of Dermatology, Stamford Skin Centre, Ho Chi Minh City, Vietnam.
J Christopher StatesDepartment of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Minh Van HoangDepartment of Dermatology, University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Funding

Mechanism for arsenic induced carcinogenesisR01ES027778 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2017 to 2026
$4.3M
NIEHS NIH HHS R01 ES027778
6 · The paper itself

Abstract

We report a case of a 46-year-old Vietnamese man who developed widespread, numerous and concurrent cutaneous squamous cell carcinomas (SCCs) in non-sun exposed skin areas after taking a traditional medicine (TM) formulation for chronic plaque psoriasis. The SCC lesions began to develop within 12-15 months after beginning the arsenic-containing TM. The patient experienced both acute and chronic symptoms consistent with arsenic exposure. Laboratory investigation of a collected hair sample showed a significant arsenic level. The TM formulation used by the patient was tested and demonstrated an extremely high concentration of arsenic.

Indexed as

ArsenicArsenic PoisoningCarcinoma, Squamous CellChronic DiseaseDiagnosis, DifferentialHumansMaleMedicine, TraditionalMiddle AgedNeoplasms, Multiple PrimaryPsoriasisSkin NeoplasmsTimeArsenicdermatologyskin cancer

Identifiers

PMID29602886
PMCPMC5884260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.