ArticleBMJ open2018
Thyroid disorders and breast cancer risk in Asian population: a nationwide population-based case-control study in Taiwan.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Benign thyroid disease and the risk of breast cancer: An updated systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Does hypothyroidism increase the risk of breast cancer: evidence from a meta-analysis.BMC cancer · 2020Pooled it
- Association between Benign Thyroid Disorders and Breast Cancer Risk in Korean Women.Cancer research and treatment · 2026Article
- Unraveling breast cancer risk with a focus on menopausal status: a large case-control study.Cancer causes & control : CCC · 2025Article
- Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer.Cell cycle (Georgetown, Tex.) · 2024Article
- Hypothyroidism and hyperthyroidism related to gynecologic cancers: a nationwide population-based cohort study.Scientific reports · 2024Article
- Association of thyroid autoimmunity with extra-thyroid diseases and the risk of mortality among adults: evidence from the NHANES.Frontiers in endocrinology · 2024Article
- Anti-TPO antibody and thyroid hormone levels in Iranian female breast cancer patients and their association with prognostic factors: a case-control study.European journal of translational myology · 2023Article
- Prevalence, incidence, and risk factors of malignancy in patients with rheumatoid arthritis: a nationwide cohort study from Korea.The Korean journal of internal medicine · 2023Observational
- Cancer and Mortality Risks of Graves' Disease in South Korea Based on National Data from 2010 to 2019.Clinical epidemiology · 2023Article
- Effects of Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes.Current issues in molecular biology · 2022Article
- Thyroid Diseases and Breast Cancer.Journal of personalized medicine · 2022Review
- Thyroid disease is associated with an increased risk of breast cancer: a systematic review and meta-analysis.Gland surgery · 2021Article
- Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors.BMC medicine · 2020Article
- Breast Cancer Risk in Postmenopausal Women with Medical History of Thyroid Disorder in the Women's Health Initiative.Thyroid : official journal of the American Thyroid Association · 2020Article
- Association Between Thyroid Disorders and Colorectal Cancer Risk in Adult Patients in Taiwan.JAMA network open · 2019Observational
- Hyperthyroidism is not a significant risk of benign prostatic hyperplasia: A nationwide population-based study.Medicine · 2018Observational
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether hyperthyroidism or hypothyroidism increases the risk of subsequent breast cancer in an Asian population.
designNationwide population-based case-control study.
settingAll healthcare facilities in Taiwan.
participantsA total of 103 466 women (mean age 53.3 years) were enrolled.
methods51 733 adult women with newly diagnosed primary breast cancer without a previous cancer history between 2006 and 2011 were identified and included in our study. 51 733 women with no cancer diagnosis prior to the index date were age matched as controls. Diagnosis of hyperthyroidism or hypothyroidism prior to the diagnosis of breast cancer or the same index date was identified, age, histories of thyroid disease treatment, oestrogen use and radioactive iodine treatment were adjusted.
main outcome measuresTo identify risk differences in developing breast cancer among patients with a medical history of hyperthyroidism or hypothyroidism.
resultsThere was a significantly increased risk of breast cancer in women with hyperthyroidism under the age of 55 years (age <45: OR 1.16, P=0.049; age 45-55: OR 1.15, P=0.019). Patients with hypothyroidism also showed an increased risk of breast cancer (OR 1.19, P=0.029) without statistical significance after stratification by age group (age <45, 45-55, >55 years). Treatment for thyroid disorders did not alter the association in subgroup analyses (P=0.857; 0.262, respectively).
conclusionsAsian women under 55 years of age with history of hyperthyroidism have a significantly increased risk of breast cancer regardless of treatment. Women with history of hypothyroidism may also have an increased risk.
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