Evidence map›Paper›PMID 29602832›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule.

Qifei Sun, Yipin Wu, Sima Jonusaite, John M Pleinis, John M Humphreys, Haixia He, Jeffrey N Schellinger, Radha Akella, Drew Stenesen, Helmut Krämer and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors.Cell communication and signaling : CCS · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Intracellular CaiScience · 2024
    Article
  10. Article
  11. Article
  12. Hydrostatic Pressure Sensing by WNK kinases.Molecular biology of the cell · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021
    Review
  17. WNKs are potassium-sensitive kinases.American journal of physiology. Cell physiology · 2021
    Article
  18. Roles of WNK4 and SPAK in KAmerican journal of physiology. Renal physiology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qifei SunDivision of Nephrology, Department of Internal Medicine and.
Yipin WuDivision of Nephrology, Department of Internal Medicine and.
Sima JonusaiteDivision of Nephrology and Hypertension, Department of Internal Medicine, Molecular Medicine Program, University of Utah, Salt Lake City, Utah.
John M PleinisDivision of Nephrology and Hypertension, Department of Internal Medicine, Molecular Medicine Program, University of Utah, Salt Lake City, Utah.
John M HumphreysDepartments of Biophysics and.
Haixia HeDepartments of Biophysics and.
Jeffrey N SchellingerDivision of Nephrology, Department of Internal Medicine and.
Radha AkellaDepartments of Biophysics and.
Drew StenesenNeuroscience, University of Texas Southwestern Medical Center, Dallas, Texas; and.
Helmut KrämerNeuroscience, University of Texas Southwestern Medical Center, Dallas, Texas; and.
Elizabeth J GoldsmithDepartments of Biophysics and.
Aylin R RodanDivision of Nephrology, Department of Internal Medicine and Aylin.rodan@hsc.utah.ORCID 0000-0001-9202-2378
University of Utah · USThe University of Texas Southwestern Medical Center · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
MOLECULAR ANALYSIS OF THE BOSS TRANSMEMBRANE LIGANDR01EY010199 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI Helmut J Kramer · 1994 to 2026
$9.7M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Basic Science Training Program in Drug Abuse ResearchT32DA007290 · NIDA · YALE UNIVERSITY · PI SELF, DAVID W · 1992 to 2017
$6.7M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
Endocytic Trafficking and Cell Signaling in Models of ARC SyndromeR01GM120196 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI KRAMER, HELMUT J · 2017 to 2020
$1.3M
WNK & SPAK/OSR1 regulation of SLC12 cotransporters in DrosophilaK08DK091316 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2011 to 2015
$727k
Probing intracellular Cl- in a WNK signaling-dependent transporting epitheliumR03DK106350 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2015 to 2016
$156k
NEI NIH HHS R01 EY010199NIDA NIH HHS T32 DA007290NIDDK NIH HHS K08 DK091316NIDDK NIH HHS R01 DK110358NIDDK NIH HHS R03 DK106350NIGMS NIH HHS R01 GM120196NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnimals, Genetically ModifiedCalcium-Binding ProteinsChloridesDrosophila melanogasterDrosophila ProteinsEpitheliumFemaleGene Knockdown TechniquesIon TransportMalpighian TubulesPhosphorylationProtein Serine-Threonine KinasesSignal TransductionCab39 protein, mouseCalcium-Binding ProteinsChloridesDrosophila Proteinsfray protein, DrosophilaMo25 protein, DrosophilaProtein Serine-Threonine KinasesWNK protein, DrosophilaCab39hypertensionhypokalemiakidneyMalpighian tubuleNKCC

Identifiers

PMID29602832
PMCPMC5967776
OpenAlexW2794452052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.