Evidence map›Paper›PMID 29602820›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody.

Kirstin A Zettlitz, Wen-Ting K Tsai, Scott M Knowles, Naoko Kobayashi, Timothy R Donahue, Robert E Reiter, Anna M Wu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Dual targeting PET tracer [Theranostics · 2025
    Article
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  8. Article
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  14. ImmunoPET/NIRF/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma.European journal of nuclear medicine and molecular imaging · 2021
    Article
  15. The clinical application ofTranslational cancer research · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kirstin A ZettlitzCrump Institute for Molecular Imaging, UCLA, Los Angeles, California kzettlitz@mednet.ucla.edu.
Wen-Ting K TsaiCrump Institute for Molecular Imaging, UCLA, Los Angeles, California.
Scott M KnowlesCrump Institute for Molecular Imaging, UCLA, Los Angeles, California.
Naoko KobayashiDavid Geffen School of Medicine, UCLA, Los Angeles, California.
Timothy R DonahueDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, California.
Robert E ReiterDavid Geffen School of Medicine, UCLA, Los Angeles, California.
Anna M WuCrump Institute for Molecular Imaging, UCLA, Los Angeles, California.
University of California, Los Angeles · USInstitute for Molecular Medicine · USUCLA Health · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Multifunctional immunoPET tracers for pancreatic and prostate cancerR01CA174294 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E, WU, ANNA M · 2013 to 2020
$3.3M
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA174294
6 · The paper itself

Abstract

Pancreatic cancer has a high mortality rate due to late diagnosis and the tendency to invade surrounding tissues and metastasize at an early stage. A molecular imaging agent that enables both presurgery antigen-specific PET (immuno-PET) and intraoperative near-infrared fluorescence (NIRF) guidance might benefit diagnosis of pancreatic cancer, staging, and surgical resection, which remains the only curative treatment.

Indexed as

Infrared RaysAnimalsAntigens, NeoplasmCell Line, TumorCell Transformation, NeoplasticGPI-Linked ProteinsIodine RadioisotopesMaleMiceNeoplasm ProteinsNeoplasm StagingOptical ImagingPositron Emission Tomography Computed TomographyProstatic NeoplasmsSingle-Chain AntibodiesTissue DistributionAntigens, NeoplasmGPI-Linked ProteinsIodine-124Iodine RadioisotopesNeoplasm ProteinsPSCA protein, humanSingle-Chain Antibodiescys-diabodyfluorescence-guided surgeryimmuno-PETpancreatic cancerprostate stem cell antigen (PSCA)

Identifiers

PMID29602820
PMCPMC6126441
OpenAlexW2795159517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.