Evidence map›Paper›PMID 29602819›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Detection Threshold and Reproducibility of

Katharina Lückerath, Andreea D Stuparu, Liu Wei, Woosuk Kim, Caius G Radu, Christine E Mona, Jeremie Calais, Matthew Rettig, Robert E Reiter, Johannes Czernin and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. PSMA-Directed Imaging and Therapy of Salivary Gland Tumors: A Single-Center Retrospective Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  6. Article
  7. Article
  8. Annals of nuclear medicine · 2021
    Review
  9. Preclinical Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  10. Day-to-day variability of [EJNMMI research · 2020
    Article
  11. Article
  12. Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  13. [American journal of nuclear medicine and molecular imaging · 2020
    Article
  14. Novel Structured Reporting Systems for Theranostic Radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Katharina LückerathDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California klueckerath@mednet.ucla.edu.
Andreea D StuparuDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Liu WeiDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Woosuk KimDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Caius G RaduDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Christine E MonaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Jeremie CalaisDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Matthew RettigDepartment of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Robert E ReiterDepartment of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Johannes CzerninDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Roger SlavikDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Ken HerrmannDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Matthias EiberDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Wolfgang P FendlerDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
University of California, Los Angeles · USGerman Cancer Research Center · DETechnical University of Munich · DE

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
PET Imaging-guided Personalized Therapy in Pancreatic CancerR01CA187678 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CZERNIN, JOHANNES, DONAHUE, TIMOTHY R · 2014 to 2018
$2.8M
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA187678
6 · The paper itself

Abstract

To improve prostate-specific membrane antigen (PSMA)-targeted theranostic approaches, robust murine models of prostate cancer are needed. However, important characteristics of preclinical PSMA imaging-that is, the reproducibility of the imaging signal and the relationship between quantitative cell surface PSMA expression and lesion detectability with small-animal PET/CT-have not been defined yet.

Indexed as

OligopeptidesPositron Emission Tomography Computed TomographyAnimalsBiological TransportCell Line, TumorDisease Models, AnimalEdetic AcidGallium IsotopesGallium RadioisotopesGene Expression Regulation, NeoplasticImage Processing, Computer-AssistedMaleMiceMice, Inbred C57BLProstatic NeoplasmsReproducibility of ResultsEdetic Acidgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesOligopeptidesPETprostate cancerPSMAreproducibilitythreshold

Identifiers

PMID29602819
PMCPMC6910618
OpenAlexW2794677852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.