Evidence map›Paper›PMID 29602806›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Oversized galactosides as a probe for conformational dynamics in LacY.

Irina Smirnova, Vladimir Kasho, Xiaoxu Jiang, Hong-Ming Chen, Stephen G Withers, H Ronald Kaback

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Function Trumps Form in Two Sugar Symporters,International journal of molecular sciences · 2021
    Review
  3. Article
  4. It takes two to tango: The dance of the permease.The Journal of general physiology · 2019
    Review
  5. Engineered occluded apo-intermediate of LacY.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Irina SmirnovaDepartment of Physiology, University of California, Los Angeles, CA 90095.
Vladimir KashoDepartment of Physiology, University of California, Los Angeles, CA 90095.
Xiaoxu JiangDepartment of Physiology, University of California, Los Angeles, CA 90095.
Hong-Ming ChenDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Stephen G WithersDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
H Ronald KabackDepartment of Physiology, University of California, Los Angeles, CA 90095; rkaback@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of British Columbia · CA

Funding

Dynamics of the Lactose Permease of Escherichia ColiR01GM120043 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, ERNEST M · 2016 to 2019
$1.8M
NIGMS NIH HHS R01 GM120043
6 · The paper itself

Abstract

Binding kinetics of α-galactopyranoside homologs with fluorescent aglycones of different sizes and shapes were determined with the lactose permease (LacY) of

Indexed as

Binding SitesBiological Transport, ActiveCrystallography, X-RayEscherichia coli ProteinsFluorescent DyesGalactoseGalactosidesKineticsLigandsModels, MolecularMolecular StructureMonosaccharide Transport ProteinsPeriplasmProtein BindingProtein ConformationStructure-Activity RelationshipEscherichia coli ProteinsFluorescent DyesGalactoseGalactosidesLacY protein, E coliLigandsMonosaccharide Transport ProteinsSymportersfluorescencelactose permeasemembrane transport proteinsnanobodiesstopped-flow

Identifiers

PMID29602806
PMCPMC5910868
OpenAlexW2794687570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.