Evidence map›Paper›PMID 29602801›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients.

Swati Khanna, Suzanne Graef, Francis Mussai, Anish Thomas, Neha Wali, Bahar Guliz Yenidunya, Constance Yuan, Betsy Morrow, Jingli Zhang, Firouzeh Korangy and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Novel and Future Treatment Options in Mesothelioma: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Pleural mesothelioma.Nature reviews. Disease primers · 2025
    Review
  4. NOX Family: Regulators of Reactive Oxygen Species Balance in Tumor Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Role of GM-CSF in lung balance and disease.Frontiers in immunology · 2023
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Swati Khanna *Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Suzanne Graef *Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Francis Mussai *Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Anish ThomasThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Neha WaliUniversity of Maryland Baltimore County, Baltimore, Maryland.
Bahar Guliz YenidunyaKoç University, Rumelifeneri, Sarıyer/İstanbul, Turkey.
Constance YuanLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Betsy MorrowThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jingli ZhangThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Firouzeh KorangyThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Tim F GretenThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Seth M SteinbergBiostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Maryalice Stetler-StevensonLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Gary Middleton *Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Carmela De Santo *Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Raffit Hassan *Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. hassanr@mail.nih.gov.
National Institutes of Health · US

Funding

Immunotherapy for Malignant Mesothelioma, Lung Cancer and Thymic MalignanciesZIABC010816 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HASSAN, RAFFIT · 2009 to 2025
$25.5M
Flow Cytometric Evaluation of BiomarkersZICBC011104 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, HAO-WEI · 2009 to 2025
$8.6M
Clinical protocols for the treatment of GI cancerZIABC011343 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRETEN, TIM · 2010 to 2025
$4.8M
Immunotherapy for Malignant MesotheliomaZ01BC010816 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HASSAN, RAFFIT · 2007 to 2008
$1.3M
Cancer Research UK 17973Intramural NIH HHS Z01 BC010816
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunomodulationBiomarkersCell Line, TumorGranulocyte-Macrophage Colony-Stimulating FactorGranulocytesHumansLung NeoplasmsLymphocyte ActivationMesotheliomaMesothelioma, MalignantMyeloid CellsReactive Oxygen SpeciesT-LymphocytesTumor MicroenvironmentBiomarkersGranulocyte-Macrophage Colony-Stimulating FactorReactive Oxygen Species

Identifiers

PMID29602801
PMCPMC6601632
OpenAlexW2794473240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.