ArticleJournal of the American Heart Association2018
Association of Left Atrial Function Index with Atrial Fibrillation and Cardiovascular Disease: The Framingham Offspring Study.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Left atrial function in elite athletes: A meta-analysis of two-dimensional speckle tracking echocardiographic studies.Clinical cardiology · 2019Pooled it
- Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.European journal of heart failure · 2020Trial
- Atrial Fibrillation Burden: Assessment, Clinical Significance, and Therapeutic Implications.Life (Basel, Switzerland) · 2026Review
- Association of Left Atrial Structure and Function with Incident Atrial Fibrillation in Black and White Adults: the ARIC Study.medRxiv : the preprint server for health sciences · 2026Article
- Correlation Between Interatrial Septal In Situ Thrombus and Stroke Evaluated by Transesophageal Echocardiography.Reviews in cardiovascular medicine · 2026Article
- Impaired left atrial strain is associated with new-onset atrial fibrillation and adverse clinical outcomes in primary care patients.Heart rhythm O2 · 2026Article
- Modifiable Lifestyle Factors, Left Atrial Indices, and Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Heart Failure and Comorbidities (Chronic Kidney Disease, Diabetes, Obesity) Management: A Multidisciplinary Approach.Cardiorenal medicine · 2026Review
- Causality of atrial fibrillation and left atrial traits: Genetic and epigenetic perspectives.Heart rhythm O2 · 2026Article
- Joint assessment of metabolic and functional indices for coronary burden: a real-world study in patients undergoing angiography for chest pain.Frontiers in cardiovascular medicine · 2026Article
- Article
- Echocardiographic Predictors of Postoperative Atrial Fibrillation After Cardiac Surgery: Assessing Atrial Mechanics for Risk Stratification.Journal of cardiovascular development and disease · 2025Article
- The power of the left atrioventricular coupling index in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
- Cardiac abnormalities and repolarization variability in epilepsy: influence of antiseizure medications and treatment response.Frontiers in cardiovascular medicine · 2025Article
- Clinical research progress on pathogenesis and treatment of Patent Foramen Ovale-associated stroke.Frontiers in neurology · 2025Review
- Right Atrial Septal In Situ Microthrombus: A Potential Novel Cause of Patent Foramen Ovale-Associated Stroke.Journal of the American Heart Association · 2024Article
- Deep learning of left atrial structure and function provides link to atrial fibrillation risk.Nature communications · 2024Article
- Pathophysiology and clinical relevance of atrial myopathy.Basic research in cardiology · 2024Review
- Impact of rs1805127 and rs55742440 Variants on Atrial Remodeling in Hypertrophic Cardiomyopathy Patients with Atrial Fibrillation: A Romanian Cohort Study.International journal of molecular sciences · 2023Article
- Incorporating uric acid into the CHA2DS2-VASc score improves the prediction of new-onset atrial fibrillation in patients with acute myocardial infarction.BMC cardiovascular disorders · 2023Article
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundLeft atrial (LA) size, a marker of atrial structural remodeling, is associated with increased risk for atrial fibrillation (AF) and cardiovascular disease (CVD). LA function may also relate to AF and CVD, irrespective of LA structure. We tested the hypothesis that LA function index (LAFI), an echocardiographic index of LA structure and function, may better characterize adverse LA remodeling and predict incident AF and CVD than existing measures. METHODS AND
resultsIn 1786 Framingham Offspring Study eighth examination participants (mean age, 66±9 years; 53% women), we related LA diameter and LAFI (derived from the LA emptying fraction, left ventricular outflow tract velocity time integral, and indexed maximal LA volume) to incidence of AF and CVD on follow-up. Over a median follow-up of 8.3 years (range, 7.5-9.1 years), 145 participants developed AF and 139 developed CVD. Mean LAFI was 34.5±12.7. In adjusted Cox regression models, lower LAFI was associated with higher risk of incident AF (hazard ratio=3.83, 95% confidence interval=2.23-6.59, lowest [Q1] compared with highest [Q4] LAFI quartile) and over 2-fold higher risk of incident CVD (hazard ratio=2.20, 95% confidence interval=1.32-3.68, Q1 versus Q4). Addition of LAFI, indexed maximum LA volume, or LA diameter to prediction models for AF or CVD did not significantly improve model discrimination for either outcome.
conclusionsIn our prospective investigation of a moderate-sized community-based sample, LAFI, a composite measure of LA size and function, was associated with incident AF and CVD. Addition of LAFI to the risk prediction models for AF or CVD, however, did not significantly improve their performance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.