Evidence map›Paper›PMID 29602632›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2018

Urinary Biomarkers of Kidney Tubular Damage and Risk of Cardiovascular Disease and Mortality in Elders.

Vasantha Jotwani, Ronit Katz, Joachim H Ix, Orlando M Gutiérrez, Michael Bennett, Chirag R Parikh, Steven R Cummings, Mark J Sarnak, Michael G Shlipak

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  11. Associations of Blood Mitochondrial DNA Quality and Quantity with Risk of Kidney Function Decline.Clinical journal of the American Society of Nephrology : CJASN · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Vasantha JotwaniDivision of Nephrology, Department of Medicine, San Francisco VA Medical Center, San Francisco, CA; Kidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, CA. Electronic address: vasantha.jotwani@ucsf.edu.
Ronit KatzKidney Research Institute, University of Washington, Seattle, WA.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, CA; Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA.
Orlando M GutiérrezDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL.
Michael BennettDivision of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Chirag R ParikhSection of Nephrology, Department of Medicine, Yale University, New Haven, CT; Program of Applied Translational Research, Yale University, New Haven, CT.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA.
Mark J SarnakDivision of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA.
Michael G ShlipakDivision of Nephrology, Department of Medicine, San Francisco VA Medical Center, San Francisco, CA; Kidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, CA.
University of California, San Francisco · USCalifornia Pacific Medical Center · USCincinnati Children's Hospital Medical Center · USTufts Medical Center · USUniversity of Alabama at Birmingham · USUniversity of California, San Diego · USUniversity of Washington · USYale University · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
Proteomics CoreP50DK096418 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI DEVARAJAN, PRASAD · 2012 to 2021
$8.4M
The Aging Kidney: Chronic Injury, Impaired Functions and Clinical OutcomesR01AG027002 · NIA · TUFTS MEDICAL CENTER · PI PARIKH, SAMIR M, SARNAK, MARK J · 2005 to 2022
$7.3M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996k
Biomarkers of Drug-induced Kidney Injury in HIVK23DK109868 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOTWANI, VASANTHA KOLAVENNU · 2016 to 2020
$993k
DYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793k
NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS R01 AG027002NIA NIH HHS R01 AG028050NIDDK NIH HHS K23 DK109868NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P50 DK096418NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

RATIONALE &

objectiveNovel urinary biomarkers have enabled earlier detection of kidney tubular damage, but their prognostic value for adverse cardiovascular outcomes is uncertain. We hypothesized that tubular damage, measured by urine α STUDY

designCase-cohort study. SETTING &

participantsThis study included a randomly selected subcohort (n=502), cardiovascular disease (CVD) cases (n=245), and heart failure cases (n=220) from the Health, Aging, and Body Composition (Health ABC) Study. PREDICTORS: Baseline urine A1M, PIIINP, and NGAL concentrations. OUTCOMES: Incident CVD, heart failure, and all-cause mortality. ANALYTICAL APPROACH: Cox proportional hazards models were used to evaluate biomarker associations with each outcome.

resultsAt baseline, mean age was 74 years and estimated glomerular filtration rate was 73mL/min/1.73m LIMITATIONS: Urine biomarkers were measured at a single time point; no validation cohort available.

conclusionsKidney tubular damage is an independent risk factor for CVD and death among elders. Future studies should investigate mechanisms by which kidney tubular damage may adversely affect cardiovascular risk.

Indexed as

AgedBiomarkersCardiovascular DiseasesCohort StudiesFemaleHumansKidney TubulesLipocalin-2MaleMortalityRandom AllocationRisk FactorsBiomarkersLCN2 protein, humanLipocalin-2amino-terminal propeptide of type III procollagen (PIIINP)cardiovascular disease (CVD)elderlyheart failure (HF)mortalityneutrophil gelatinase-associated lipocalin (NGAL)prognosticationtubular injury markersUrine biomarkerα(1)-microglobulin (A1M)

Identifiers

PMID29602632
PMCPMC6057830
OpenAlexW2795186745

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.