Evidence map›Paper›PMID 29602396›Full record

ReviewSeminars in nephrology2018

Lipidomics and Biomarker Discovery in Kidney Disease.

Farsad Afshinnia, Thekkelnaycke M Rajendiran, Stefanie Wernisch, Tanu Soni, Adil Jadoon, Alla Karnovsky, George Michailidis, Subramaniam Pennathur

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes.Annals of clinical and translational neurology · 2022
    Article
  13. Review
  14. The foundations and development of lipidomics.Journal of lipid research · 2022
    Review
  15. Review
  16. Article
  17. Perspectives in systems nephrology.Cell and tissue research · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Farsad AfshinniaDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI.
Thekkelnaycke M RajendiranMichigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI; Department of Pathology, University of Michigan, Ann Arbor, MI.
Stefanie WernischDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI.
Tanu SoniMichigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI.
Adil JadoonDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI.
Alla KarnovskyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI.
George MichailidisMichigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI; Department of Statistics, University of Florida, Gainesville, FL.
Subramaniam PennathurDepartment of Internal Medicine-Nephrology, University of Michigan, Ann Arbor, MI; Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI. Electronic address: spennath@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9M
Prognostic Biomarkers in Chronic Kidney DiseaseK08DK106523 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AFSHINNIA, FARSAD · 2015 to 2019
$789k
NIDDK NIH HHS K08 DK106523NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK081943NIDDK NIH HHS P30 DK089503
6 · The paper itself

Abstract

Technological advances in mass spectrometry-based lipidomic platforms have provided the opportunity for comprehensive profiling of lipids in biological samples and shown alterations in the lipidome that occur in metabolic disorders. A lipidomic approach serves as a powerful tool for biomarker discovery and gaining insight to molecular mechanisms of disease, especially when integrated with other -omics platforms (ie, transcriptomics, proteomics, and metabolomics) in the context of systems biology. In this review, we describe the workflow commonly applied to the conduct of lipidomic studies including important aspects of study design, sample preparation, biomarker identification and quantification, and data processing and analysis, as well as crucial considerations in clinical applications. We also review some recent studies of the application of lipidomic platforms that highlight the potential of lipid biomarkers and add to our understanding of the molecular basis of kidney disease.

Indexed as

Lipid MetabolismStatistics as TopicBig DataBiomarkersElectronic Data ProcessingHumansKidney DiseasesLipidsQuality ControlWorkflowBiomarkersLipidsbiomarkersLipidomicsmass spectrometrymetabolomics

Identifiers

PMID29602396
PMCPMC5881936
OpenAlexW2794865171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.