Evidence map›Paper›PMID 29602139›Full record

ReviewAtherosclerosis2018

New methods to image unstable atherosclerotic plaques.

Jack P M Andrews, Zahi A Fayad, Marc R Dweck

Open access · bronzeAbstract readReview
In one paragraph

Review in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Review
  3. Why Current Detection of Vascular Calcification Falls Short and How to Improve on It.TH open : companion journal to thrombosis and haemostasis · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Imaging of atherosclerosis with [Scientific reports · 2023
    Article
  8. Article
  9. Nanotechnology for cardiovascular diseases.Innovation (Cambridge (Mass.)) · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Atherosclerosis Imaging withDiagnostics (Basel, Switzerland) · 2020
    Review
  14. An Update on [Journal of lipid and atherosclerosis · 2020
    Review
  15. Review
  16. Coronary Atherosclerosis Imaging.Diagnostics (Basel, Switzerland) · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Vulnerable Plaque, Characteristics, Detection, and Potential Therapies.Journal of cardiovascular development and disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jack P M AndrewsCentre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, Royal Infirmary of Edinburgh, Edinburgh EH16 4SB, UK.
Zahi A FayadTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: zahi.fayad@mssm.edu.
Marc R DweckCentre for Cardiovascular Science, University of Edinburgh, Chancellor's Building, Royal Infirmary of Edinburgh, Edinburgh EH16 4SB, UK.
University of Edinburgh · GBIcahn School of Medicine at Mount Sinai · US

Funding

Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
Ga68-DOTATATE PET imaging of plaque inflammationR01HL135878 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2017 to 2020
$2.9M
Cardiovascular Inflammation Reduction Trial (CIRT) - Inflammation Imaging StudyR01HL128056 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2015 to 2018
$2.6M
British Heart Foundation FS/14/78/31020British Heart Foundation FS/17/51/33096Medical Research Council G0701127NHLBI NIH HHS P01 HL131478NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL128056NHLBI NIH HHS R01 HL135878NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

Atherosclerotic plaque rupture is the primary mechanism responsible for myocardial infarction and stroke, the top two killers worldwide. Despite being potentially fatal, the ubiquitous prevalence of atherosclerosis amongst the middle aged and elderly renders individual events relatively rare. This makes the accurate prediction of MI and stroke challenging. Advances in imaging techniques now allow detailed assessments of plaque morphology and disease activity. Both CT and MR can identify certain unstable plaque characteristics thought to be associated with an increased risk of rupture and events. PET imaging allows the activity of distinct pathological processes associated with atherosclerosis to be measured, differentiating patients with inactive and active disease states. Hybrid integration of PET with CT or MR now allows for an accurate assessment of not only plaque burden and morphology but plaque biology too. In this review, we discuss how these advanced imaging techniques hold promise in redefining our understanding of stable and unstable coronary artery disease beyond symptomatic status, and how they may refine patient risk-prediction and the rationing of expensive novel therapies.

Indexed as

Annexin A5ApoptosisAtherosclerosisCoronary Artery DiseaseDiagnostic ImagingFluorodeoxyglucose F18Gallium RadioisotopesHumansHypoxiaInflammationLigandsMagnetic Resonance ImagingMyocardial InfarctionNeovascularization, PhysiologicPlaque, AtheroscleroticPositron-Emission TomographyAnnexin A5Fluorodeoxyglucose F18Gallium RadioisotopesLigandsRadiopharmaceuticalsComputed tomographyPositron emission tomographyUnstable plaque

Identifiers

PMID29602139
PMCPMC6463488
OpenAlexW2792254882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.