Evidence map›Paper›PMID 29601946›Full record

ArticleFree radical biology & medicine2018

Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

Dieanira Erudaitius, Jacqueline Mantooth, Andrew Huang, Jesse Soliman, Claire M Doskey, Garry R Buettner, Victor G J Rodgers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Balanced Duality: HInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dieanira ErudaitiusDepartment of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
Jacqueline MantoothDepartment of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
Andrew HuangDepartment of Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.
Jesse SolimanDepartment of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
Claire M DoskeyCenter for Integrative Toxicology, Michigan State University, East Lansing, MI 48823, USA.
Garry R BuettnerFree Radical & Radiation Biology, Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
Victor G J RodgersDepartment of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: victor.rodgers@ucr.edu.
University of California, Riverside · USMichigan State University · USUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
UC Riverside MARC U* Star Undergraduate Research ProgramT34GM062756 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2001 to 2022
$8.7M
The chemical biology of pharmacological ascorbate in cancer treatmentR01CA169046 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA169046NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T34 GM062756
6 · The paper itself

Abstract

The high extracellular hydrogen peroxide (H

Indexed as

Models, TheoreticalAntineoplastic AgentsAscorbic AcidCell Line, TumorDrug Resistance, NeoplasmHumansHydrogen PeroxideAntineoplastic AgentsAscorbic AcidHydrogen PeroxideCatalaseCytosolHydrogen peroxideIntracellular hydrogen peroxide concentrationMathematical modelParameter sensitivityPeroxisome permeabilityPharmacological ascorbate therapyPlasma membrane permeabilityTransport properties of cells

Identifiers

PMID29601946
PMCPMC6160292
OpenAlexW2795267434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.