Evidence map›Paper›PMID 29601894›Full record

ArticleAntiviral research2018

Susceptibility of paramyxoviruses and filoviruses to inhibition by 2'-monofluoro- and 2'-difluoro-4'-azidocytidine analogs.

Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T Nichol, Christina F Spiropoulou

Open access · greenAbstract read
In one paragraph

Article in Antiviral research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  8. Broad-SpectrumMicrobiology spectrum · 2021
    Article
  9. Article
  10. Anno 2021: Which antivirals for the coming decade?Annual reports in medicinal chemistry · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Michael K LoUS Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mko2@cdc.gov.
Paul C JordanAlios BioPharma, Inc., a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, CA, USA.
Sarah StevensAlios BioPharma, Inc., a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, CA, USA.
Yuen TamAlios BioPharma, Inc., a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, CA, USA.
Jerome DevalAlios BioPharma, Inc., a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, CA, USA.
Stuart T NicholUS Centers for Disease Control and Prevention, Atlanta, GA, USA.
Christina F SpiropoulouUS Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ccs8@cdc.gov.
Johnson & Johnson (United States) · USCenters for Disease Control and Prevention · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4'-azidocytidine (4'N

Indexed as

Antiviral AgentsCytidineEbolavirusHenipavirusMarburgvirusMicrobial Sensitivity Tests4'-azidocytidineAntiviral AgentsCytidineAntiviralEbola virusFilovirusHenipavirusNipah virusNucleoside analogParamyxovirusR1479

Identifiers

PMID29601894
PMCPMC6066796
OpenAlexW2795201548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.