ArticleVirus research2019
The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes.
Article in Virus research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Not an infection: Endogenous circoviral elements underlie BFDV detections in Old World vultures.PloS one · 2026Article
- HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements.Bioinformatics (Oxford, England) · 2025Article
- Article
- Aquatic circoviruses: emerging pathogens in global aquaculture - from discovery to disease management.Journal of virology · 2025Review
- Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes.Nature microbiology · 2024Article
- Epidemiological and evolutionary analysis of canine circovirus from 1996 to 2023.BMC veterinary research · 2024Article
- A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus fossil record.Genome biology · 2024Article
- Identification of small circular DNA viruses in coyote fecal samples from Arizona (USA).Archives of virology · 2023Article
- A Diverse Virome Is Identified in Parasitic Flatworms of Domestic Animals in Xinjiang, China.Microbiology spectrum · 2023Article
- Vertebrate-tropism of a cressdnavirus lineage implicated by poxvirus gene capture.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Circoviruses and cycloviruses identified in Weddell seal fecal samples from McMurdo Sound, Antarctica.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Viruses Infecting the European Catfish (Viruses · 2021Review
- Ancient evolution of hepadnaviral paleoviruses and their impact on host genomes.Virus evolution · 2021Article
- Entamoeba and Giardia parasites implicated as hosts of CRESS viruses.Nature communications · 2020Article
- Novel Circoviruses Detected in Feces of Sonoran Felids.Viruses · 2020Article
- Virus-Host Coevolution with a Focus on Animal and Human DNA Viruses.Journal of molecular evolution · 2020Review
- The first reptilian circovirus identified infects gut and liver tissues of black-headed pythons.Veterinary research · 2019Article
- A Review on Viral Metagenomics in Extreme Environments.Frontiers in microbiology · 2019Review
- Insights into Circovirus Host Range from the Genomic Fossil Record.Journal of virology · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain relatively poorly understood. Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in vertebrate genomes. CVe are a useful source of information about the biology and evolution of circoviruses. In this study, we screened 362 vertebrate genome assemblies in silico to generate a catalog of CVe loci. We identified a total of 179 CVe sequences, most of which have not been reported previously. We show that these CVe loci reflect at least 19 distinct germline integration events. We determine the structure of CVe loci, identifying some that show evidence of potential functionalization. We also identify orthologous copies of CVe in snakes, fish, birds, and mammals, allowing us to add new calibrations to the timeline of circovirus evolution. Finally, we observed that some ancient CVe group robustly with contemporary circoviruses in phylogenies, with all sequences within these groups being derived from the same host class or order, implying a hitherto underappreciated stability in circovirus-host relationships. The openly available dataset constructed in this investigation provides new insights into circovirus evolution, and can be used to facilitate further studies of circoviruses and CVe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.