Evidence map›Paper›PMID 29601653›Full record

ArticleJournal of veterinary internal medicine2018

Angiostrongylosis in dogs with negative fecal and in-clinic rapid serological tests: 7 Cases (2013-2017).

A Morgane Canonne, F Billen, B Losson, I Peters, M Schnyder, C Clercx

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  6. New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 5 countries.

A Morgane CanonneDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium.ORCID http://orcid.org/0000-0002-9263-1744
F BillenDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium.
B LossonLaboratory of Parasitology and Parasitic Diseases, University of Liège, Belgium.
I PetersTDDS Laboratories, University of Exeter, Exeter, Devon, London, United Kingdom.
M SchnyderInstitute of Parasitology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
C ClercxDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium.
University of Liège · BEUniversity of Exeter · GBUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAngiostrongylosis is considered as emerging disease in dogs in Belgium. Detection of first-stage larvae in feces using the Baermann method has an imperfect sensitivity.

objectivesInvestigation of efficacy of noninvasive blood and fecal diagnostic tests in comparison with PCR on bronchoalveolar lavage (BAL) material in a small series of coughing or dyspnoeic dogs naturally infected with Angiostrongylus vasorum. ANIMALS: Seven dogs with angiostrongylosis.

methodsRetrospective study. Dogs with cough, exercise intolerance and dyspnea of 2- to 8-week duration. Diagnostic methods used included Baermann analysis, AngioDetect rapid assay, ELISAs for detection of circulating antigen and specific antibodies and qPCR on BAL material.

resultsBaermann analysis, AngioDetect rapid assay, antigen ELISA, antibody ELISA, and qPCR on BAL material were positive in 3/7, 2/7, 3/6, 6/6, and 7/7 dogs, respectively. ELISA for antibodies or qPCR on BAL material were essential for definitive diagnosis in 3 dogs. Relative sensitivities of AngioDetect rapid assay, Baermann analysis, and ELISA for antigen detection were lower than 50% compared with ELISA for antibodies or qPCR on BAL material. CONCLUSION AND CLINICAL IMPORTANCE: In this small clinical series, Baermann analysis and AngioDetect rapid assay failed to confirm the diagnosis in some dogs. Therefore, ELISA for antibody detection and qPCR on BAL material should strongly be considered in clinically suspected dogs when antigen detection methods (AngioDetect or ELISA) and Baermann analysis are negative.

Indexed as

AngiostrongylusAnimalsBronchoalveolar LavageDog DiseasesDogsEnzyme-Linked Immunosorbent AssayFalse Negative ReactionsFecesFemaleMalePolymerase Chain ReactionRetrospective StudiesSensitivity and SpecificityStrongylida InfectionsAngioDetectbronchoalveolar lavageqPCRserology

Identifiers

PMID29601653
PMCPMC5980360
OpenAlexW2794519749

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.