Evidence map›Paper›PMID 29601574›Full record

ArticlePLoS biology2018

Dynamic frontotemporal systems process space and time in working memory.

Elizabeth L Johnson, Jenna N Adams, Anne-Kristin Solbakk, Tor Endestad, Pål G Larsson, Jugoslav Ivanovic, Torstein R Meling, Jack J Lin, Robert T Knight

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Human Beta Oscillations Reflect Magnitude and Fidelity of Priority Shifts in Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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  13. Cortical and white matter substrates supporting visuospatial working memory.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Theta-Alpha Connectivity in the Hippocampal-Entorhinal Circuit Predicts Working Memory Load.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth L JohnsonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, United States of America.ORCID 0000-0001-5297-5019
Jenna N AdamsHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, United States of America.
Anne-Kristin SolbakkDepartment of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.
Tor EndestadDepartment of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.
Pål G LarssonDepartment of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.
Jugoslav IvanovicDepartment of Neurosurgery, Division of Clinical Neuroscience, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Torstein R MelingDepartment of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway.
Jack J LinComprehensive Epilepsy Program, Department of Neurology, University of California, Irvine, Irvine, California, United States of America.
Robert T KnightHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, United States of America.

Funding

Attention, Orientation and the Human Prefrontal CortexR01NS021135 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI Robert Thomas Knight · 1985 to 2026
$6.5M
ATTENTION, ORIENTATION, & THE HUMAN PREFRONTAL CORTEXR37NS021135 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KNIGHT, ROBERT THOMAS · 2013 to 2019
$3.6M
NINDS NIH HHS R01 NS021135NINDS NIH HHS R37 NS021135
6 · The paper itself

Abstract

How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL-PFC interactions underlie working memory for everyday experiences.

Indexed as

Memory, Short-TermAdultBrain MappingFemaleHumansMalePrefrontal CortexTemporal LobeTheta Rhythm

Identifiers

PMID29601574
PMCPMC5895055

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.