Evidence map›Paper›PMID 29601533›Full record

ReviewSensors (Basel, Switzerland)2018

Aptamer-Modified Magnetic Beads in Biosensing.

Harshvardhan Modh, Thomas Scheper, Johanna-Gabriela Walter

Abstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Harshvardhan ModhInstitute of Technical Chemistry, Leibniz University of Hannover, Hannover 30167, Germany. modh@iftc.uni-hannover.de.ORCID 0000-0001-7651-337X
Thomas ScheperInstitute of Technical Chemistry, Leibniz University of Hannover, Hannover 30167, Germany. scheper@iftc.uni-hannover.de.
Johanna-Gabriela WalterInstitute of Technical Chemistry, Leibniz University of Hannover, Hannover 30167, Germany. walter@iftc.uni-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes. Moreover, aptamers facilitate novel sensing strategies based on their oligonucleotide nature that cannot be realized with conventional peptide-based ligands. Due to these benefits, the combination of aptamers and MBs was already used in various analytical applications which are summarized in this article.

Indexed as

Immunomagnetic SeparationAntibodiesAptamers, NucleotideBiosensing TechniquesSELEX Aptamer TechniqueAntibodiesAptamers, Nucleotideanalytical applicationsaptamerelectrochemical assaysmagnetic beadsoptical assayspoint-of-care-testing

Identifiers

PMID29601533
PMCPMC5948603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.