ArticleJournal of functional biomaterials2018
Short-Term Degradation of Bi-Component Electrospun Fibers: Qualitative and Quantitative Evaluations via AFM Analysis.
Article in Journal of functional biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of Functionalization of the Polycaprolactone Film Surface on the Mechanical and Biological Properties of the Film Itself.Polymers · 2022Article
- Enhanced In Vitro Biocompatible Polycaprolactone/Nano-Hydroxyapatite Scaffolds with Near-Field Direct-Writing Melt Electrospinning Technology.Journal of functional biomaterials · 2022Article
- Detection of HOCl-driven degradation of the pericardium scaffolds by label-free multiphoton fluorescence lifetime imaging.Scientific reports · 2022Article
- Surface coating materials regulates the attachment and differentiation of mouse embryonic stem cell derived embryoid bodies into mesoderm at culture conditions.Cytotechnology · 2022Article
- Electrospun PCL-Based Vascular Grafts: In Vitro Tests.Nanomaterials (Basel, Switzerland) · 2021Article
- Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications.Polymers · 2020Review
- Long-term hydrolytic degradation study of polycaprolactone films and fibers grafted with poly(sodium styrene sulfonate): Mechanism study and cell response.Biointerphases · 2020Article
- Article
- Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospun polymeric fibers are currently used as 3D models for in vitro applications in biomedical areas, i.e., tissue engineering, cell and drug delivery. The high customization of the electrospinning process offers numerous opportunities to manipulate and control surface area, fiber diameter, and fiber density to evaluate the response of cells under different morphological and/or biochemical stimuli. The aim of this study was to investigate-via atomic force microscopy (AFM)-the chemical and morphological changes in bi-component electrospun fibers (BEFs) during the in vitro degradation process using a biological medium. BEFs were fabricated by electrospinning a mixture of synthetic-polycaprolactone (PCL)-and natural polymers (gelatin) into a binary solution. During the hydrolytic degradation of protein, no significant remarkable effects were recognized in terms of fiber integrity. However, increases in surface roughness as well as a decrease in fiber diameter as a function of the degradation conditions were detected. We suggest that morphological and chemical changes due to the local release of gelatin positively influence cell behavior in culture, in terms of cell adhesion and spreading, thus working to mimic the native microenvironment of natural tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.