Evidence map›Paper›PMID 29601469›Full record

ReviewMolecules (Basel, Switzerland)2018

Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications.

Christy Manyi-Loh, Sampson Mamphweli, Edson Meyer, Anthony Okoh

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 701 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
701citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

701 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Prevalence and antimicrobial resistance ofOpen veterinary journal · 2025
    Pooled it
  5. Pooled it
  6. Article
  7. Article
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  10. Sales of antimicrobials for veterinary use, Bangladesh, 2023.Bulletin of the World Health Organization · 2026
    Article
  11. Article
  12. Article
  13. AApplied and environmental microbiology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

641 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christy Manyi-LohFort Hare Institute of Technology, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. cmanyi-loh@ufh.ac.za.
Sampson MamphweliFort Hare Institute of Technology, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. smamphweli@ufh.ac.za.
Edson MeyerFort Hare Institute of Technology, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. emeyer@ufh.ac.za.
Anthony OkohApplied and Environmental Microbiology Research Group (AEMREG), Department of Biochemistry and Microbiology, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. aokoh@ufh.ac.za.ORCID 0000-0002-9770-085X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the increased demand of animal protein in developing countries, intensive farming is instigated, which results in antibiotic residues in animal-derived products, and eventually, antibiotic resistance. Antibiotic resistance is of great public health concern because the antibiotic-resistant bacteria associated with the animals may be pathogenic to humans, easily transmitted to humans via food chains, and widely disseminated in the environment via animal wastes. These may cause complicated, untreatable, and prolonged infections in humans, leading to higher healthcare cost and sometimes death. In the said countries, antibiotic resistance is so complex and difficult, due to irrational use of antibiotics both in the clinical and agriculture settings, low socioeconomic status, poor sanitation and hygienic status, as well as that zoonotic bacterial pathogens are not regularly cultured, and their resistance to commonly used antibiotics are scarcely investigated (poor surveillance systems). The challenges that follow are of local, national, regional, and international dimensions, as there are no geographic boundaries to impede the spread of antibiotic resistance. In addition, the information assembled in this study through a thorough review of published findings, emphasized the presence of antibiotics in animal-derived products and the phenomenon of multidrug resistance in environmental samples. This therefore calls for strengthening of regulations that direct antibiotic manufacture, distribution, dispensing, and prescription, hence fostering antibiotic stewardship. Joint collaboration across the world with international bodies is needed to assist the developing countries to implement good surveillance of antibiotic use and antibiotic resistance.

Indexed as

Animal HusbandryAnimalsAnti-Bacterial AgentsBacteriaDrug Resistance, BacterialHumansSocioeconomic FactorsAnti-Bacterial Agentsagricultureantibiotic resistanceantibioticsdeveloping countriesenvironmental sources

Identifiers

PMID29601469
PMCPMC6017557

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.