Evidence map›Paper›PMID 29600809›Full record

Trial reportEpilepsia2018

Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial.

Nicholas M Barbaro, Mark Quigg, Mariann M Ward, Edward F Chang, Donna K Broshek, John T Langfitt, Guofen Yan, Kenneth D Laxer, Andrew J Cole, Penny K Sneed and 17 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Epilepsia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Surgery for epilepsy.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Trial
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  9. Article
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  12. Review
  13. Article
  14. Article
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  17. Journal of radiosurgery and SBRT · 2025
    Article
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 3 countries.

Nicholas M BarbaroDepartment of Neurological Surgery, Indiana University, Indianapolis, IN, USA.
Mark QuiggDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3035-9260
Mariann M WardDepartment of Neurosurgery, University of California San Francisco, San Francisco, CA, USA.
Edward F ChangDepartment of Neurosurgery, University of California San Francisco, San Francisco, CA, USA.
Donna K BroshekDepartment of Psychiatry, University of Virginia, Charlottesville, VA, USA.
John T LangfittDepartment of Neurology, University of Rochester, Rochester, NY, USA.
Guofen YanDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Kenneth D LaxerDepartment of Neurology, California Pacific Medical Center, San Francisco, CA, USA.
Andrew J ColeDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0828-826X
Penny K SneedDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
Christopher P HessDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Wei YuDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Manjari TripathiDepartment of Neurology, All India Institute of Medical Science, New Delhi, India.
Christianne N HeckDepartment of Neurology, University of Southern California, Los Angeles, CA, USA.
John W MillerDepartment of Neurology, University of Washington, Seattle, WA, USA.
Paul A GarciaDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Andrew McEvoyDepartment of Clinical and Experimental Epilepsy, University College London, London, UK.
Nathan B FountainDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
Vincenta SalanovaDepartment of Neurology, Indiana University, Indianapolis, IN, USA.
Robert C KnowltonDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Anto BagićDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Thomas HenryDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Siddharth KapoorDepartment of Neurology, University of Kentucky, Lexington, KY, USA.
Guy McKhannDepartment of Neurosurgery, Columbia University, New York, NY, USA.
Adriana E PaladeDepartment of Neurology, University of Louisville, Louisville, KY, USA.
Markus ReuberDepartment of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-4104-6705
Evelyn TecomaDepartment of Neurology, University of California San Diego, San Diego, CA, USA.
University of California, San Francisco · USUniversity of Virginia · USAll India Institute of Medical Sciences · INCalifornia Pacific Medical Center · USColumbia University · USEpilepsy Research UK · GBIndiana University Indianapolis · USMassachusetts General Hospital · USNeurological Surgery · USUniversity of California San Diego · USUniversity of Kentucky · USUniversity of Louisville · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Rochester · USUniversity of Sheffield · GBUniversity of Southern California · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare stereotactic radiosurgery (SRS) versus anterior temporal lobectomy (ATL) for patients with pharmacoresistant unilateral mesial temporal lobe epilepsy (MTLE).

methodsThis randomized, single-blinded, controlled trial recruited adults eligible for open surgery among 14 centers in the USA, UK, and India. Treatment was either SRS at 24 Gy to the 50% isodose targeting mesial structures, or standardized ATL. Outcomes were seizure remission (absence of disabling seizures between 25 and 36 months), verbal memory (VM), and quality of life (QOL) at 36-month follow-up.

resultsA total of 58 patients (31 in SRS, 27 in ATL) were treated. Sixteen (52%) SRS and 21 (78%) ATL patients achieved seizure remission (difference between ATL and SRS = 26%, upper 1-sided 95% confidence interval = 46%, P value at the 15% noninferiority margin = .82). Mean VM changes from baseline for 21 English-speaking, dominant-hemisphere patients did not differ between groups; consistent worsening occurred in 36% of SRS and 57% of ATL patients. QOL improved with seizure remission. Adverse events were anticipated cerebral edema and related symptoms for some SRS patients, and cerebritis, subdural hematoma, and others for ATL patients. SIGNIFICANCE: These data suggest that ATL has an advantage over SRS in terms of proportion of seizure remission, and both SRS and ATL appear to have effectiveness and reasonable safety as treatments for MTLE. SRS is an alternative to ATL for patients with contraindications for or with reluctance to undergo open surgery.

Indexed as

AdultAnterior Temporal LobectomyDose-Response Relationship, RadiationDrug Resistant EpilepsyEpilepsy, Temporal LobeFemaleFunctional LateralityHumansLongitudinal StudiesMaleMemory DisordersMiddle AgedPostoperative ComplicationsQuality of LifeRadiosurgerySingle-Blind Methodclinical trialepilepsy surgeryfocal epilepsyquality of liferadiosurgery

Identifiers

PMID29600809
OpenAlexW2795041137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.