Evidence map›Paper›PMID 29600541›Full record

ReviewAngewandte Chemie (International ed. in English)2018

Human Enzymes for Organic Synthesis.

Margit Winkler, Martina Geier, Steven P Hanlon, Bernd Nidetzky, Anton Glieder

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Human Enzymes for Organic Synthesis.Angewandte Chemie (International ed. in English) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Margit WinklerInstitute for Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria.ORCID 0000-0002-0754-9704
Martina Geieracib GmbH, Petersgasse 14, 8010, Graz, Austria.
Steven P HanlonF. Hoffmann-La Roche, 4070, Basel, Switzerland.
Bernd Nidetzkyacib GmbH, Petersgasse 14, 8010, Graz, Austria.ORCID 0000-0002-5030-2643
Anton GliederInstitute for Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria.ORCID 0000-0002-5986-9689

Funding

Austrian Science Fund FWF Elise-Richter
6 · The paper itself

Abstract

Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

Indexed as

EnzymesHumansEnzymesbiocatalysisbiotransformationdrug metaboliteshuman enzymespharmaceutical compounds

Identifiers

PMID29600541
PMCPMC6334177

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.