ArticleThe journal of physiological sciences : JPS2019
Isoflurane anesthesia does not affect spinal cord neurovascular coupling: evidence from decerebrated rats.
Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Customized ultra-flexible and adhesive spinal cord stimulation electrode for chronic pain management.Materials today. Bio · 2026Article
- Article
- Contrast-Enhanced Ultrasound Imaging Detects Anatomical and Functional Changes in Rat Cervical Spine Microvasculature With Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Effect of medetomidine, midazolam, ketamine, propofol and isoflurane on spinal reflexes in healthy dogs.Veterinary medicine and science · 2022Article
- Mechanism of dexmedetomidine preconditioning on spinal cord analgesia in rats with functional chronic visceral pain.Acta cirurgica brasileira · 2022Article
- Contribution of astrocytes to neurovascular coupling in the spinal cord of the rat.The journal of physiological sciences : JPS · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools for following functional changes in the course of injury, disease and rehabilitation. However, the relationship between neuronal activity and blood flow in the spinal cord on which fMRI relies has been largely overlooked. The objective of this study was to examine neurovascular coupling in the spinal cord of decerebrated rats during electrical stimulation of the sciatic nerve with and without isoflurane anesthesia (1.2%). Local field potentials (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement. Isoflurane did not significantly alter LFP (p = 0.53) and SCBF (p = 0.57) amplitude. Accordingly, neurovascular coupling remained comparable with or without isoflurane anesthesia (p = 0.39). These results support the use of isoflurane in rodents to investigate nociceptive functions of the spinal cord using fMRI.
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