Evidence map›Paper›PMID 29600390›Full record

Trial reportJournal of neurology2018

Supervised versus unsupervised technology-based levodopa monitoring in Parkinson's disease: an intrasubject comparison.

Giovanna Lopane, Sabato Mellone, Mattia Corzani, Lorenzo Chiari, Pietro Cortelli, Giovanna Calandra-Buonaura, Manuela Contin

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanna LopaneLaboratory of Clinical Neuropharmacology, Neurology Clinic, IRCCS-Institute of Neurological Sciences of Bologna, Via Altura 1/8, 40139, Bologna, Italy.
Sabato MellonePersonal Health Systems Lab, Department of Electrical, Electronic, and Information Engineering, University of Bologna, Bologna, Italy.
Mattia CorzaniPersonal Health Systems Lab, Department of Electrical, Electronic, and Information Engineering, University of Bologna, Bologna, Italy.
Lorenzo ChiariPersonal Health Systems Lab, Department of Electrical, Electronic, and Information Engineering, University of Bologna, Bologna, Italy.
Pietro CortelliLaboratory of Clinical Neuropharmacology, Neurology Clinic, IRCCS-Institute of Neurological Sciences of Bologna, Via Altura 1/8, 40139, Bologna, Italy.
Giovanna Calandra-BuonauraLaboratory of Clinical Neuropharmacology, Neurology Clinic, IRCCS-Institute of Neurological Sciences of Bologna, Via Altura 1/8, 40139, Bologna, Italy.
Manuela ContinLaboratory of Clinical Neuropharmacology, Neurology Clinic, IRCCS-Institute of Neurological Sciences of Bologna, Via Altura 1/8, 40139, Bologna, Italy. manuela.contin@unibo.it.ORCID http://orcid.org/0000-0001-6399-9999

Funding

Fondazione del Monte di Bologna e Ravenna 451bis/2015
6 · The paper itself

Abstract

We aimed to assess the intrasubject reproducibility of a technology-based levodopa (LD) therapeutic monitoring protocol administered in supervised versus unsupervised conditions in patients with Parkinson's disease (PD). The study design was pilot, intrasubject, single center, open and prospective. Twenty patients were recruited. Patients performed a standardized monitoring protocol instrumented by an ad hoc embedded platform after their usual first morning LD dose in two different randomized ambulatory sessions: one under a physician's supervision, the other self-administered. The protocol is made up of serial motor and non-motor tests, including alternate finger tapping, Timed Up and Go test, and measurement of blood pressure. Primary motor outcomes included comparisons of intrasubject LD subacute motor response patterns over the 3-h test in the two experimental conditions. Secondary outcomes were the number of intrasession serial test repetitions due to technical or handling errors and patients' satisfaction with the unsupervised LD monitoring protocol. Intrasubject LD motor response patterns were concordant between the two study sessions in all patients but one. Platform handling problems averaged 4% of total planned serial tests for both sessions. Ninety-five percent of patients were satisfied with the self-administered LD monitoring protocol. To our knowledge, this study is the first to explore the potential of unsupervised technology-based objective motor and non-motor tasks to monitor subacute LD dosing effects in PD patients. The results are promising for future telemedicine applications.

Indexed as

AgedAntiparkinson AgentsComputers, HandheldDrug MonitoringFemaleHealth CommunicationHumansLevodopaMaleMiddle AgedMotor ActivityParkinson DiseasePatient SatisfactionPhysiciansPilot ProjectsReproducibility of ResultsAntiparkinson AgentsLevodopaAlternate finger tapping testInformation and communication technologyLevodopaParkinson’s diseaseTherapeutic drug monitoringTimed Up and Go test

Identifiers

PMID29600390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.