Evidence map›Paper›PMID 29600291›Full record

ArticleBiostatistics & epidemiology2017

Multi-state models and missing covariate data: Expectation-Maximization algorithm for likelihood estimation.

Wenjie Lou, Lijie Wan, Erin L Abner, David W Fardo, Hiroko H Dodge, Richard J Kryscio

Abstract read
In one paragraph

Article in Biostatistics & epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  3. Article
  4. Estimating Population-Based Recurrence Rates of Colorectal Cancer over Time in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenjie LouDepartment of Statistics, University of Kentucky.
Lijie WanDepartment of Statistics, University of Kentucky.
Erin L AbnerDepartment of Biostatistics, University of Kentucky.
David W FardoDepartment of Biostatistics, University of Kentucky.
Hiroko H DodgeDepartment of Neurology, C. Rex and Ruth H. Layton Center for Alzheimer's Research, Oregon Health and Science University.
Richard J KryscioDepartment of Statistics, University of Kentucky.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 1990 to 2019
$27.7M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI SCHMITT, FREDERICK · 2006 to 2020
$23.3M
Role of impaired cognitive states & risk factors in conversion to mixed dementiasR01AG038651 · NIA · UNIVERSITY OF KENTUCKY · PI ABNER, ERIN, KRYSCIO, RICHARD J. · 2011 to 2023
$6.1M
NCATS NIH HHS UL1 TR001998NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG028383NIA NIH HHS R01 AG038651
6 · The paper itself

Abstract

Multi-state models have been widely used to analyze longitudinal event history data obtained in medical and epidemiological studies. The tools and methods developed recently in this area require completely observed data. However, missing data within variables of interest is very common in practice, and it has been an issue in applications. We propose a type of EM algorithm, which handles missingness within multiple binary covariates efficiently, for multi-state model applications. Simulation studies show that the EM algorithm performs well for both missing completely at random (MCAR) and missing at random (MAR) covariate data. We apply the method to a longitudinal aging and cognition study dataset, the Klamath Exceptional Aging Project (KEAP), whose data were collected at Oregon Health & Science University and integrated into the Statistical Models of Aging and Risk of Transition (SMART) database at the University of Kentucky.

Indexed as

EM algorithmMARMCARmissing covariatesMulti-state model

Identifiers

PMID29600291
PMCPMC5869000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.