Evidence map›Paper›PMID 29600287›Full record

ArticlemSystems

Carolyn A Brotherton, Marnix H Medema, E Peter Greenberg

Abstract read
In one paragraph

Article in mSystems. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Rethinking Biosynthesis of Aclacinomycin A.Molecules (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. AntarcticFrontiers in microbiology · 2022
    Article
  11. Article
  12. Article
  13. Frontiers in cellular and infection microbiology · 2021
    Article
  14. Chimeric LuxR Transcription Factors Rewire Natural Product Regulation.Angewandte Chemie (International ed. in English) · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carolyn A BrothertonDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Marnix H MedemaBioinformatics Group, Wageningen University, Wageningen, The Netherlands.ORCID https://orcid.org/0000-0002-2191-2821
E Peter GreenbergDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-9474-8041

Funding

QUORUM SENSING IN PSEUDOMONAS AERUGINOSAR01GM059026 · NIGMS · UNIVERSITY OF WASHINGTON · PI GREENBERG, EVERETT P · 1999 to 2019
$6.5M
NIGMS NIH HHS R01 GM059026
6 · The paper itself

Abstract

Microbes are a major source of antibiotics, pharmaceuticals, and other bioactive compounds. The production of many specialized microbial metabolites is encoded in biosynthetic gene clusters (BGCs). A challenge associated with natural product discovery is that many BGCs are not expressed under laboratory growth conditions. Here we report a genome-mining approach to discover BGCs with

Indexed as

quorum sensingsecondary metabolism

Identifiers

PMID29600287
PMCPMC5872303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.