ArticleSouth Asian journal of cancer
Incidental gallbladder carcinoma: Utility of histopathological evaluation of routine cholecystectomy specimens.
Article in South Asian journal of cancer. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Selective or Routine Histology of Cholecystectomy Specimens for Diagnosing Incidental Carcinoma of Gallbladder and Correlation with Careful Intraoperative Macroscopic Examination? A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Safe, selective histopathological examination of gallbladder specimens: a systematic review.The British journal of surgery · 2020Pooled it
- Non-invasive predictive model for incidental gallbladder carcinoma based on multimodal features: Integrating clinical data, MRI radiomics, and deep transfer learning features.Translational oncology · 2026Article
- Incidental Gallbladder Cancer After Cholecystectomy for Presumed Benign Biliary Disease: A Sixteen-Year Retrospective Cohort Study from a Tertiary Referral Center.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Incidental diagnosis of gallbladder carcinoma during or after routine cholecystectomy: A retrospective study with emphasis on clinicopathologic findings.World journal of clinical oncology · 2025Article
- Incidental Gallbladder Cancer: A Comprehensive Review.Journal of gastrointestinal cancer · 2025Review
- Post-operative complications of cholecystectomy: what the radiologist needs to know.Abdominal radiology (New York) · 2025Review
- Article
- Advancements in Cholelithiasis Diagnosis: A Systematic Review of Machine Learning Applications in Imaging Analysis.Cureus · 2024Review
- Incidental gallbladder cancer: what is the prevalence and how do we perform cholecystectomy for presumably benign biliary disease?Revista do Colegio Brasileiro de Cirurgioes · 2023Observational
- Article
- Thirty-five cases of gallbladder carcinoma out of 4914 cholecystectomy specimens from a Nepalese tertiary care hospital - A retrospective cohort study.Annals of medicine and surgery (2012) · 2021Article
- Article
- Segnet Network Algorithm-Based Ultrasound Images in the Diagnosis of Gallbladder Stones Complicated with Gallbladder Carcinoma and the Relationship between P16 Expression with Gallbladder Carcinoma.Journal of healthcare engineering · 2021Article
- A Comparative Analysis of Clinical Characteristics and Histomorphologic and Immunohistochemical Spectrum of Gallbladder Carcinoma in Young Adults (< 45 Years) and Elderly Adults (> 60 Years).Indian journal of surgical oncology · 2020Article
- Incidental Carcinoma after Cholecystectomy for Benign Disease of the Gallbladder: A Meta-Analysis.Journal of clinical medicine · 2020Article
- Laparoscopic Cholecystectomy for Symptomatic Cholecystic Disease in Children: Defining Surgical Timing.Frontiers in pediatrics · 2020Article
- Article
- Letter to Editor: Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign Gallbladder Disease.World journal of surgery · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncidental gallbladder carcinoma (IGBC) is rare cancer diagnosed during or after cholecystectomy done for benign gallbladder disease. The concern whether routine histopathological examination is needed for all cholecystectomy specimens still remains debatable. MATERIALS AND
methodsTwenty patients diagnosed with IGBC over a period of 2 years were retrospectively reviewed. Clinical details including clinical presentation, preoperative ultrasound (USG) findings, and macroscopic features were retrieved. Diagnosis of IGBC was confirmed on microscopic examination, and staging was done using the tumor node metastasis staging system.
resultsOf the 4800 cholecystectomy specimens retrieved, diagnosis of IGBC was rendered in twenty cases (0.41%). Mean patient age was 50.65 years with a female preponderance. Preoperative USG detected an increase in wall thickness in six cases (30%) in contrast to gross examination which revealed the same in 55% (11/20) cases. Mucosal ulceration was observed in two cases (10%) of IGBC and seven cases (35%) did not reveal any preoperative or macroscopic findings suggestive of malignancy. Associated cholelithiasis was observed in 14 cases. Final diagnosis of IGBC was made on histomorphological assessment with tumor cells infiltrating the lamina propria in three cases (pT1b), muscularis propria in 15 cases (pT1b), and serosa in the remaining 2 cases (pT2).
conclusionIGBC is a clinical masquerader which often evades the eye of a radiologist and comes as pathological surprise. Histopathological examination of cholecystectomy specimens remains the gold standard for the detection of this occult, yet notorious malignancy and assessment of the depth of invasion in IGBC guide further management.
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