ArticleInternational journal of ophthalmology2018
Low concentration of sodium hyaluronate temporarily elevates the tear film lipid layer thickness in dry eye patients with lipid deficiency.
Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- A scoping review of integrated blink analysis technologies for ocular surface diseases.Eye (London, England) · 2026Review
- Interactions of Mucomimetic Polymers and Meibomian Surface Films upon Exposure to Environmental Stressors.Biomolecules · 2026Article
- Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires.Frontiers in medicine · 2024Article
- Assessment of tear film parameters post-treatment with commercial eyelid cleaning wipes: a pilot study.International journal of ophthalmology · 2024Article
- Lipid, Aqueous and Mucin Tear Film Layer Stability and Permanence within 0.15% Liposome Crosslinked Hyaluronic Acid versus 0.15% Non-Crosslinked Hyaluronic Acid Measured with a Novel Non-Invasive Ocular Surface Analyzer.Journal of clinical medicine · 2022Article
- Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Interactions of Meibum and Tears with Mucomimetic Polymers: A Hint towards the Interplay between the Layers of the Tear Film.International journal of molecular sciences · 2021Article
- Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease.Diagnostics (Basel, Switzerland) · 2020Review
- Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update.International journal of molecular sciences · 2019Review
- Changes of tear film lipid layer thickness by 3% diquafosol ophthalmic solutions in patients with dry eye syndrome.International journal of ophthalmology · 2019Article
- Morphological and cytological changes of meibomian glands in patients with type 2 diabetes mellitus.International journal of ophthalmology · 2019Article
- Effect of Ultrasonic Moisture Glasses on Dry Eye Signs and Symptoms.Translational vision science & technology · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of different concentrations of artificial tears on lipid layer thickness (LLT) and blink rate (BR) in dry eye patients.
methodsThis study included 106 eyes of 58 patients with dry eye. The lipid deficiency type was defined as the LLT baseline <75 nm. The LLT and BR were measured at baseline and 1, 5 and 15min after the instillation of 0.1% or 0.3% sodium hyaluronate (SH) eye drops by using the LipiView ocular surface interferometer.
resultsIn the lipid deficiency group, the LLT increased from baseline at 1min post instillation. The LLT after the instillation of 0.1% SH was significantly higher than that after the instillation of 0.3% SH (
conclusionSH eye drops induce a short-term increase in LLT of patients with lipid deficiency. A low concentration of artificial tears have a stronger effect than a high concentration of artificial tears on the increase in LLT. In comparison, SH eye drops induce a transient and slight decrease in LLT of patients without lipid deficiency. A low concentration of artificial tears might be better for patients with lipid deficiency.
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