Evidence map›Paper›PMID 29600167›Full record

ArticleInternational journal of ophthalmology2018

Protective effects of a composition of Chinese herbs-Gurigumu-13 on retinal ganglion cell apoptosis in DBA/2J glaucoma mouse model.

Qiu-Li Zhang, Wei Wang, Yan Jiang, Tian-Zi Zhang, Zhan-Jun Lu, Ao Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Qiu-Li ZhangDepartment of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, the Inner Mongolia Autonomous Region, China.
Wei WangDepartment of Ophthalmology, Tongliao Hospital, Tongliao 028000, the Inner Mongolia Autonomous Region, China.
Yan JiangDepartment of Neurosurgery, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, the Inner Mongolia Autonomous Region, China.
Tian-Zi ZhangDepartment of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, the Inner Mongolia Autonomous Region, China.
Zhan-Jun LuDepartment of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, the Inner Mongolia Autonomous Region, China.
Ao JiangChina-Japan Union Hospital of Jilin University, Changchun 130000, Jilin Province, China.
Inner Mongolia University for Nationalities · CNJilin University · CNTongliao Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the concrete mechanism of a Mongolian compound medicine-Gurigumu-13 (GRGM) for glaucoma treatment.

methodsDBA/2J mice, as glaucoma models, were intragastric administrated with GRGM to study the effect of GRGM on retinal ganglion cells (RGCs). The loss of RGCs was evaluated with the number of RGCs and axons. The expression of the target protein of RGCs or mouse retinas was determined by Western blot. The relative content of malondialdehyde (MDA) was examined by ELISA assay.

resultsGRGM distinctly improved retina damage

conclusionGRGM have obvious protective effects on RGCs in DBA/2J mice, and increase the number of RGCs and axons

Indexed as

endoplasmic reticulum stressglaucomaoxidative stressretinal ganglion cells

Identifiers

PMID29600167
PMCPMC5861223
OpenAlexW2800252670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.