ArticleJournal of thoracic disease2018
Esophageal cancer in elderly patients: a population-based study.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021.Biomarker research · 2025Article
- Gastro-Esophageal Cancer: Can Radiomic Parameters from BaselineDiagnostics (Basel, Switzerland) · 2024Article
- Survival trends and conditional survival in primary non-metastatic esophageal cancer: a SEER population-based study and external validation.Translational cancer research · 2023Article
- Identification of Metastatic Lymph Nodes Using Indocyanine Green Fluorescence Imaging.Cancers · 2023Article
- Risk factors of oesophageal cancer at health facilities in Addis Ababa, Ethiopia: Unmatched case control study.Frontiers in oncology · 2022Article
- Survival Comparison Between Squamous Cell Carcinoma and Adenocarcinoma for Radiotherapy-Treated Patients with Stage IIB-IVA Cervical Cancer.Frontiers in oncology · 2022Article
- Feasibility of esophagectomy for esophageal cancer in elderly patients: a case-control study.Langenbeck's archives of surgery · 2021Article
- Surgery provides improved overall survival in surgically fit octogenarians with esophageal cancer after chemoradiation therapy.Journal of thoracic disease · 2021Article
- Esophageal Cancer in Elderly Patients, Current Treatment Options and Outcomes; A Systematic Review and Pooled Analysis.Cancers · 2021Review
- Review
- Nomogram based on immune scores for predicting the survival of patients with esophageal squamous cell carcinoma.The Journal of international medical research · 2021Article
- Metastasis Patterns and Prognosis of Elderly Patients With Esophageal Adenocarcinoma in Stage IVB: A Population-Based Study.Frontiers in oncology · 2021Article
- Treatments and outcomes of older patients with esophageal cancer: Comparison with younger patients.Molecular and clinical oncology · 2019Article
- Investigation into the expression levels of MAGEA6 in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues.Experimental and therapeutic medicine · 2019Article
- UGT2B17 and miR-224 contribute to hormone dependency trends in adenocarcinoma and squamous cell carcinoma of esophagus.Bioscience reports · 2019Article
- Comparison of Outcomes Between McKeown and Sweet Esophagectomy in the Elderly Patients for Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis.Cancer control : journal of the Moffitt Cancer CenterArticle
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21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs the aging issue and increased elderly esophageal cancer (EC) patients, we sought to study the clinical characteristics, treatment modality and outcomes of EC patients 70 years or older compared with those younger than 70 years old.
methodsThe national surveillance, epidemiology, and end results (SEER) database for the period from 1973 to 2013 was analyzed. The patient and treatment characteristics were compared between the age groups. Multivariate Cox proportional hazard regression analyses were also performed to identify independent prognostic factors. Propensity-score matching analyses (PSA) regarding survival after different treatments were also performed in locoregional EC.
resultsCompared with the younger group, patients 70 years or older were characterized by having a higher proportion of patients with female gender, white race, localized disease, non-adenocarcinoma and without any treatment, as well as inferior overall survival (OS) [hazard ratio (HR), 1.324] and EC-specific survival (HR, 1.270). In addition, older patients shared same independent prognostic factors with younger patients, including age, histology and race. Specifically, compared with those receiving no intensive treatments, surgery alone (HR, 0.342), both surgery and RT (HR, 0.323) and RT only (HR, 0.525) were favorable among elderly patients, as confirmed by both multivariate adjustment and PSA.
conclusionsCompared to younger EC patients, those 70 years or older showed distinctive clinical characteristics and inferior survival. Despite showing a higher proportion of localized disease, patients 70 years or older were less likely to be subjected to surgery or/and RT. Thus, the role of intensive treatments, which were identified as favorable factors among elderly patients in this study, warrants further investigation.
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