Evidence map›Paper›PMID 29600060›Full record

ArticleJournal of thoracic disease2018

Positive correlation between postoperative tumor recurrence and changes in circulating tumor cell counts in pulmonary venous blood (pvCTC) during surgical manipulation in non-small cell lung cancer.

Masaki Hashimoto, Fumihiro Tanaka, Kazue Yoneda, Teruhisa Takuwa, Seiji Matsumoto, Yoshitomo Okumura, Nobuyuki Kondo, Tohru Tsujimura, Takashi Nakano, Seiki Hasegawa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Masaki HashimotoDepartment of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Fumihiro TanakaSecond Department of Surgery (Chest Surgery), University of Occupational and Environmental Health, Kitakyushu, Japan.
Kazue YonedaSecond Department of Surgery (Chest Surgery), University of Occupational and Environmental Health, Kitakyushu, Japan.
Teruhisa TakuwaDepartment of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Seiji MatsumotoDepartment of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Yoshitomo OkumuraDepartment of Thoracic Surgery, Itami City Hospital, Itami, Japan.
Nobuyuki KondoDepartment of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Tohru TsujimuraDepartment of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Takashi NakanoCenter for Respiratory Medicine, Otemae Hospital, Osaka, Japan.
Seiki HasegawaDepartment of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Hyogo Medical University · JPUniversity of Occupational and Environmental Health Japan · JPItami City Hospital · JPOtemae Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn non-small cell lung cancer (NSCLC), circulating tumor cells (CTC) are shed and circulate to the peripheral blood through the pulmonary vein. Previously, CTC count in pulmonary venous blood (pvCTC) was shown to significantly increase after surgical manipulation. Therefore, we assessed the correlation between the changes in the pvCTC count (ΔpvCTC) and clinical outcomes.

methodsConsecutive patients with peripheral-type, NSCLC, who underwent lobectomy or bi-lobectomy through open thoracotomy, were enrolled prospectively. Before and after lobectomy, 2.5 mL of blood was drawn from the associated lobar pulmonary vein (PV), and was served for the quantitative evaluation of CTC using the CellSearch

resultsA total of 30 patients were enrolled, tumor recurrence occurred in 11 patients over a median follow-up of 64.4 months. Of these, 7 patients had distant metastasis and 4 had local recurrence. The median ΔpvCTC was 49 cells/2.5 mL, and pvCTC-count was increased during surgical manipulation in 24 patients (80%). We divided patients into two groups based on ΔpvCTC with the cut-off value as 119 cells/2.5 mL according to ROC curve. Significant shorter time to distant metastasis (TDM) (P=0.0123) was observed in high ΔpvCTC group (ΔpvCTC ≥119 cells/2.5 mL) than low ΔpvCTC group (ΔpvCTC <119 cells/ 2.5mL). Neither disease-free survival (DFS) nor overall survival (OS) was significantly correlated with ΔpvCTC.

conclusionsIncreasing pvCTC count during surgical manipulation was significantly correlated with postoperative distant metastasis in completely resected NSCLC patients. Significant shorter TDM was observed in patient with high ΔpvCTC group.

Indexed as

Circulating tumor cells (CTCs)non-small cell lung cancer (NSCLC)surgical manipulation

Identifiers

PMID29600060
PMCPMC5863181
OpenAlexW2776675631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.