ArticleOncotarget2018
Tooth loss and cancer risk: a dose-response meta analysis of prospective cohort studies.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026Pooled it
- Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses.Frontiers in oncology · 2025Pooled it
- 2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.European urology · 2023Pooled it
- Tooth loss and the risk of cognitive decline and dementia: A meta-analysis of cohort studies.Frontiers in neurology · 2023Pooled it
- Hematopoietic and lymphatic cancers in patients with periodontitis: a systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- An Assessment of the Sensory Function in the Maxillofacial Region: A Dual-Case Pilot Study.Sensors (Basel, Switzerland) · 2025Article
- Correlation Between Periodontal Disease and Oral, Oropharyngeal, and Parapharyngeal Cancers.Clinical, cosmetic and investigational dentistry · 2025Article
- Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016.British journal of cancer · 2022Article
- Association between tamoxifen and tooth loss in women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Genetic contribution to cancer risk in patients with tooth loss: a genetic association study.Scientific reports · 2022Article
- Tooth Loss and Risk of Lung Cancer among Urban Chinese Adults: A Cohort Study with Meta-Analysis.Cancers · 2022Article
- Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer.Frontiers in microbiology · 2022Review
- Baseline Oral Microbiome and All-cancer Incidence in a Cohort of Nonsmoking Mexican American Women.Cancer prevention research (Philadelphia, Pa.) · 2021Article
- From Beyond the Pale to the Pale Riders: The Emerging Association of Bacteria with Oral Cancer.Journal of dental research · 2020Article
- Number of Teeth and All-Cause and Cancer Mortality in a Japanese Community: The Takayama Study.Journal of epidemiology · 2020Article
- Relationship between the state of tongue hygiene and the number of residual teeth in convalescent-ward inpatients, cross- sectional study.BMC oral health · 2019Article
- The potential role ofInfectious agents and cancer · 2019Review
- The association of tooth loss, toothbrushing, and quality of life among cancer survivors.Cancer medicine · 2018Article
- Tooth Loss Is Associated With Increased Risk of Dementia and With a Dose-Response Relationship.Frontiers in aging neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflicting results to identify the relationship between tooth loss and cancer risk. Therefore, a dose-response meta-analysis was performed to clarify and quantitative assessed the correlation between tooth loss and cancer risk. Up to March 2017, 25 observational epidemiological studies were included in current meta-analysis. Tooth loss was significantly associated with a higher risk of cancer. Additionally, tooth loss was associated with significantly a higher risk of esophageal cancer, gastric cancer, head and neck cancer, colorectal cancer, pancreas cancer, lung cancer, prostate cancer, bladder cancer and hematopoietic cancer. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between tooth loss and cancer risk. Increasing per 10 of tooth loss was associated with a 9% increment of cancer risk, 14% increment of esophageal cancer risk, 9% increment of gastric cancer risk, 31% increment of head and neck cancer risk, 4% increment of colorectal cancer risk, 7% increment of pancreas cancer risk, 19% increment of lung cancer risk, 2% increment of bladder cancer risk and 3% increment of hematopoietic cancer risk. Considering these promising results, tooth loss might be harmful for health. Large sample size, different ethnic population and different cancer type are warranted to validate this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.