Evidence map›Paper›PMID 29599920›Full record

ArticleOncotarget2018

Molecular dissection of engraftment in a xenograft model of myelodysplastic syndromes.

Mathieu Meunier, Charles Dussiau, Natacha Mauz, Anne Sophie Alary, Christine Lefebvre, Gautier Szymanski, Mylène Pezet, Françoise Blanquet, Olivier Kosmider, Sophie Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Humanized mouse models in MDS.Cell death & disease · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Mathieu MeunierUniversity Clinic of Hematology, CHU Grenoble Alpes, Grenoble, France.
Charles DussiauHématologie Biologique, Hôpital Cochin, Assistance Publique-Hôpitaux De Paris, Paris, France.
Natacha MauzUniversity Clinic of Hematology, CHU Grenoble Alpes, Grenoble, France.
Anne Sophie AlaryHématologie Biologique, Hôpital Cochin, Assistance Publique-Hôpitaux De Paris, Paris, France.
Christine LefebvreLaboratory of Hematology, Onco-Genetic and Immunology, Biology and Pathology Institute, Grenoble, France.
Gautier SzymanskiLaboratory of Hematology, Onco-Genetic and Immunology, Biology and Pathology Institute, Grenoble, France.
Mylène PezetOptical Microscopy and Flow cytometry Core, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France.
Françoise BlanquetPlate-Forme De Haute Technologie Animale, UMR5525, Grenoble Alpes University, Grenoble, France.
Olivier KosmiderHématologie Biologique, Hôpital Cochin, Assistance Publique-Hôpitaux De Paris, Paris, France.
Sophie ParkUniversity Clinic of Hematology, CHU Grenoble Alpes, Grenoble, France.
Hôpital Cochin · FRCentre Hospitalier Universitaire de Grenoble · FRCentre National de la Recherche Scientifique · FRInserm · FRUniversité Grenoble Alpes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelodysplastic syndromes (MDS) are oligoclonal disorders of the hematopoietic stem cells (HSC). Recurrent gene mutations are involved in the MDS physiopathology along with the medullar microenvironment. To better study the heterogeneity of MDS, it is necessary to create patient derived xenograft (PDX). We have reproduced a PDX model by xenografting HSC (CD34

Indexed as

bone marrow microenvironmentmesenchymal stromal cellsmutational hierarchymyelodysplastic syndromepatient derived xenograft

Identifiers

PMID29599920
PMCPMC5871091
OpenAlexW2792774495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.