Evidence map›Paper›PMID 29599780›Full record

ArticleFrontiers in immunology2018

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jamie A LopezCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Tahereh NooriCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Adrian MinsonDepartment of Clinical Haematology, Austin Health, Heidelberg, VIC, Australia.
Lu Li JovanoskaCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Kevin ThiaCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Michael S HildebrandDepartment of Medicine, Austin Health, Heidelberg, VIC, Australia.
Hedieh AkhlaghiCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Phillip K DarcyCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Michael H KershawCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Natasha J BrownDepartment of Clinical Genetics, Austin Health, Heidelberg, VIC, Australia.
Andrew GriggDepartment of Clinical Haematology, Austin Health, Heidelberg, VIC, Australia.
Joseph A TrapaniCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Ilia VoskoboinikCancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Peter MacCallum Cancer Centre · AUAustin Health · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in

Indexed as

AllelesCell LineCytotoxicity, ImmunologicFemaleHumansKiller Cells, NaturalLeukocytes, MononuclearMiddle AgedMunc18 ProteinsMutationT-Lymphocytes, CytotoxicMunc18 ProteinsSTXBP1 protein, humanSTXBP2 protein, humanapoptosiscytotoxic lymphocytescytotoxic T cellsfamilial haemophagocytic lymphohistiocytosisimmunodeficiencyMunc18-1Munc18-2natural killer cells

Identifiers

PMID29599780
PMCPMC5862791
OpenAlexW2793156840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.