Evidence map›Paper›PMID 29599717›Full record

ArticleFrontiers in aging neuroscience2018

Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults.

Mara Ten Kate, Pieter Jelle Visser, Hovagim Bakardjian, Frederik Barkhof, Sietske A M Sikkes, Wiesje M van der Flier, Philip Scheltens, Harald Hampel, Marie-Odile Habert, Bruno Dubois and 1 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  7. Review
  8. Brain Network Organization and Aging.Advances in experimental medicine and biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mara Ten KateAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Pieter Jelle VisserAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Hovagim BakardjianDépartement de Neurologie, Pitié-Salpêtrière University Hospital, Institut de la Mémoire et de la Maladie d'Alzheimer, Paris, France.
Frederik BarkhofDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Sietske A M SikkesAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Wiesje M van der FlierAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Philip ScheltensAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.
Harald HampelDépartement de Neurologie, Pitié-Salpêtrière University Hospital, Institut de la Mémoire et de la Maladie d'Alzheimer, Paris, France.
Marie-Odile HabertNuclear Medicine Department, Laboratoire d'Imagerie Biomédicale, Sorbonne Universités, Pitié-Salpêtrière University Hospital, Paris, France.
Bruno DuboisDépartement de Neurologie, Pitié-Salpêtrière University Hospital, Institut de la Mémoire et de la Maladie d'Alzheimer, Paris, France.
Betty M TijmsAlzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accumulation of amyloid plaques is one of the earliest pathological changes in Alzheimer's disease (AD) and may occur 20 years before the onset of symptoms. Examining associations between amyloid pathology and other early brain changes is critical for understanding the pathophysiological underpinnings of AD. Alterations in gray matter networks might already start at early preclinical stages of AD. In this study, we examined the regional relationship between amyloid aggregation measured with positron emission tomography (PET) and gray matter network measures in elderly subjects with subjective memory complaints. Single-subject gray matter networks were extracted from T1-weigthed structural MRI in cognitively normal subjects (

Indexed as

Alzheimer’s diseaseamyloid betagraph theorygray matter networkMRIPETsubjective memory complaints

Identifiers

PMID29599717
PMCPMC5863592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.