Evidence map›Paper›PMID 29599530›Full record

ArticleGene therapy2018

Excessive activated T-cell proliferation after anti-CD19 CAR T-cell therapy.

Wen-Ying Zhang, Yang Liu, Yao Wang, Jing Nie, Ye-Lei Guo, Chun-Meng Wang, Han-Ren Dai, Qing-Ming Yang, Zhi-Qiang Wu, Wei-Dong Han

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Gene therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wen-Ying ZhangBiotherapeutic Department, Chinese PLA General Hospital, Beijing, 100853, China.
Yang LiuDepartment of Geriatric Hematology, Chinese PLA General Hospital, Beijing, 100853, China.
Yao WangDepartment of Immunology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China.
Jing NieDepartment of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China.
Ye-Lei GuoDepartment of Immunology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China.
Chun-Meng WangBiotherapeutic Department, Chinese PLA General Hospital, Beijing, 100853, China.
Han-Ren DaiDepartment of Immunology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China.
Qing-Ming YangBiotherapeutic Department, Chinese PLA General Hospital, Beijing, 100853, China.
Zhi-Qiang WuDepartment of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China. wuzhiqiang1006@163.com.
Wei-Dong HanBiotherapeutic Department, Chinese PLA General Hospital, Beijing, 100853, China. hanwdrsw69@yahoo.com.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive activated T-cell proliferation was observed in vivo in one patient after an anti-CD19-chimeric antigen receptor (CAR) T-cell infusion. The patient, who had chemotherapy refractory and CD19

Indexed as

AdultAntigens, CD19CD8-Positive T-LymphocytesCell ProliferationCytokinesHumansImmunotherapyImmunotherapy, AdoptiveInterleukinsLymphocyte ActivationLymphocyte CountMaleNeoplasmsReceptors, Antigen, T-CellT-LymphocytesAntigens, CD19CytokinesInterleukinsReceptors, Antigen, T-Cell

Identifiers

PMID29599530
OpenAlexW2794941976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.