ArticleScientific reports2018
Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
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- MALDI-TOF lipidomics rapidly detects modification of 2-hydroxymyristate lipid A, a potential virulence trait inMicrobiology spectrum · 2025Article
- First identification and whole-genome characterization of human-associated Enterobacter roggenkampii and Enterobacter sichuanensis carrying blaJournal of global antimicrobial resistance · 2025Article
- Epidemiological insight into bacterial risk associated with flooded areas of city agglomeration (Wrocław, Poland 2024).Scientific reports · 2025Article
- Lasso peptides: A focus on therapeutic index.World journal of microbiology & biotechnology · 2025Review
- Poultry slaughterhouse wastewater as a source of bacterial antimicrobial resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Investigation of Carriers ofAnimals : an open access journal from MDPI · 2024Article
- Microbiological Quality of Coconut Water Sold in the Grande Vitória Region, Brazil, and Phenogenotypic Antimicrobial Resistance of Associated Enterobacteria.Microorganisms · 2024Article
- Distribution and diversity of type VI secretion system clusters inMicrobial genomics · 2023Article
- Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022.Journal of clinical microbiology · 2023Review
- Point-Counterpoint: What's in a Name? Clinical Microbiology Laboratories Should Use Nomenclature Based on Current Taxonomy.Journal of clinical microbiology · 2023Article
- Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population.Pathogens (Basel, Switzerland) · 2023Article
- Cross-Over Pathogenic Bacteria Detected in Infected Tomatoes (Pathogens (Basel, Switzerland) · 2022Article
- Resistance on the rise: Assessment of antibiotic-resistant indicator organisms in Shem Creek, Charleston, South Carolina.Dialogues in health · 2022Article
- Emergence of a Novel Lineage and Wide Spread of aAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nosocomial pathogens can cause life-threatening infections in neonates and immunocompromised patients. E. bugandensis (EB-247) is a recently described species of Enterobacter, associated with neonatal sepsis. Here we demonstrate that the extended spectrum ß-lactam (ESBL) producing isolate EB-247 is highly virulent in both Galleria mellonella and mouse models of infection. Infection studies in a streptomycin-treated mouse model showed that EB-247 is as efficient as Salmonella Typhimurium in inducing systemic infection and release of proinflammatory cytokines. Sequencing and analysis of the complete genome and plasmid revealed that virulence properties are associated with the chromosome, while antibiotic-resistance genes are exclusively present on a 299 kb IncHI plasmid. EB-247 grew in high concentrations of human serum indicating septicemic potential. Using whole genome-based transcriptome analysis we found 7% of the genome was mobilized for growth in serum. Upregulated genes include those involved in the iron uptake and storage as well as metabolism. The lasso peptide microcin J25 (MccJ25), an inhibitor of iron-uptake and RNA polymerase activity, inhibited EB-247 growth. Our studies indicate that Enterobacter bugandensis is a highly pathogenic species of the genus Enterobacter. Further studies on the colonization and virulence potential of E. bugandensis and its association with septicemic infection is now warranted.
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