Evidence map›Paper›PMID 29599409›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer.

Chang Xu, Olga Nikolova, Ryan S Basom, Ryan M Mitchell, Reid Shaw, Russell D Moser, Heuijoon Park, Kay E Gurley, Michael C Kao, Carlos L Green and 10 more

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  13. Annual review of cancer biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Chang XuDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.
Olga NikolovaComputational Biology Program, School of Medicine, Oregon Health & Science University, Portland, Oregon.
Ryan S BasomShared Resources, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Ryan M MitchellDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.
Reid ShawCure First, Seattle, Washington.
Russell D MoserHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Heuijoon ParkClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-3296-3667
Kay E GurleyHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Michael C KaoClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Carlos L GreenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Franz X SchaubCure First, Seattle, Washington.
Robert L DiazCure First, Seattle, Washington.
Hallie A SwanCure First, Seattle, Washington.
In S JangSage Bionetworks, Seattle, Washington.
Justin GuinneySage Bionetworks, Seattle, Washington.
Vijayakrishna K GadiClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Adam A MargolinComputational Biology Program, School of Medicine, Oregon Health & Science University, Portland, Oregon.
Carla GrandoriCure First, Seattle, Washington.
Christopher J KempHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. cjkemp@fredhutch.org.
Eduardo MéndezDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.
First Tee of Greater Seattle · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAFred Hutch Cancer Center · USOregon Health & Science University · USSage Bionetworks · USSeattle Cancer Care Alliance · USUniversity of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Research Training in OtolaryngologyT32DC000018 · NIDCD · UNIVERSITY OF WASHINGTON · PI STONE, JENNIFER S. · 1989 to 2023
$7.8M
Personalized cancer models to discover and develop new therapeutic targets.U01CA217883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KEMP, CHRISTOPHER J · 2017 to 2021
$4.3M
An integrated computational and functional genomics discovery engine for precliniU01CA176303 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KEMP, CHRISTOPHER J · 2013 to 2016
$4.1M
An Academic-Industry Partnership to Advance Functional Genomics for Personalized Oncology.R01CA214428 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KEMP, CHRISTOPHER J · 2018 to 2022
$3.0M
Exploiting WEE1/p53 synthetic lethality as a novel therapy in head and neck cancerR01CA215647 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CLURMAN, BRUCE E, KEMP, CHRISTOPHER J · 2017 to 2021
$2.0M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA214428NCI NIH HHS R01 CA215647NCI NIH HHS U01 CA176303NCI NIH HHS U01 CA217883NIDCD NIH HHS T32 DC000018
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, TumorMolecular Targeted TherapyPrecision MedicineAntineoplastic AgentsComparative Genomic HybridizationComputational BiologyExome SequencingGene Expression ProfilingGenomicsHead and Neck NeoplasmsHumansMaleMiddle AgedMutationPositron-Emission TomographyRNA, Small InterferingAntineoplastic AgentsBiomarkers, TumorRNA, Small Interfering

Identifiers

PMID29599409
PMCPMC6004257
OpenAlexW2795277562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.