Evidence map›Paper›PMID 29599383›Full record

ArticleBMJ case reports2018

Ethics of a therapeutic trial: addressing limitations of an active intervention in optic nerve lymphoma.

Rohan Bir Singh, Sahil Thakur, Parul Ichhpujani, Suresh Kumar

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rohan Bir SinghDepartment of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-2426-3900
Sahil ThakurDepartment of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India.
Parul IchhpujaniDepartment of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India.
Suresh KumarDepartment of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India.
Government Medical College and Hospital · INHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a unique case of optic nerve lymphoma after completion of chemotherapy for non-Hodgkin's lymphoma. The uncommon nature of presentation, our therapeutic dilemma and the further course of treatment are reported. In cases with extremely poor prognosis, unnecessary treatment puts additional strain both financially and psychologically on the patients and their family. Therapeutic focus should be on hospice care and family counselling. The decision to not treat is a crucial component of cancer management; however, the ethics of this decision are yet to be suitably addressed by the literature.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsFatal OutcomeFemaleHumansLymphoma, Non-HodgkinMagnetic Resonance ImagingMiddle AgedNeoplasms, Second PrimaryOptic NerveOptic Nerve NeoplasmsPalliative CareTerminally Illchemotherapyethicsophthalmologyradiotherapyvisual pathway

Identifiers

PMID29599383
PMCPMC5878265
OpenAlexW2795088605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.