Evidence map›Paper›PMID 29599293›Full record

ArticleThe Journal of biological chemistry2018

TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha.

Jer-Sheng Lin, Panayiota Pissaridou, Hsin-Hui Wu, Ming-Daw Tsai, Alain Filloux, Erh-Min Lai

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Science advances · 2025
    Article
  3. mBio · 2024
    Article
  4. T6SS nuclease effectors inJournal of bacteriology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Transcriptional organization and regulation of theMicrobiology (Reading, England) · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Secrete or perish: The role of secretion systems inComputational and structural biotechnology journal · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jer-Sheng LinFrom the Institute of Plant and Microbial Biology and.
Panayiota Pissaridouthe Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Hsin-Hui Wuthe Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan and.
Ming-Daw Tsaithe Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan and.ORCID 0000-0003-1374-0414
Alain Fillouxthe Medical Research Council Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-1307-0289
Erh-Min LaiFrom the Institute of Plant and Microbial Biology and emlai@gate.sinica.edu.tw.ORCID 0000-0003-3630-8683
Imperial College London · GBInstitute of Biological Chemistry, Academia Sinica · TWInstitute of Plant and Microbial Biology, Academia Sinica · TW

Funding

Biotechnology and Biological Sciences Research Council BB/M02735X/1Biotechnology and Biological Sciences Research Council BB/N002539/1Medical Research Council MR/K001930/1Medical Research Council MR/N023250/1
6 · The paper itself

Abstract

The bacterial type VI secretion system (T6SS) delivers effectors into eukaryotic host cells or toxins into bacterial competitor for survival and fitness. The T6SS is positively regulated by the threonine phosphorylation pathway (TPP) and negatively by the T6SS-accessory protein TagF. Here, we studied the mechanisms underlying TagF-mediated T6SS repression in two distinct bacterial pathogens,

Indexed as

Protein Interaction MapsAgrobacterium tumefaciensAmino Acid SequenceBacterial ProteinsGene Expression Regulation, BacterialHumansMutagenesis, Site-DirectedPhosphorylationPlant TumorsPseudomonas aeruginosaPseudomonas InfectionsType VI Secretion SystemsBacterial ProteinsType VI Secretion SystemsAgrobacterium tumefaciensantibacterial activitybacterial geneticsFhagene regulationpost-translational regulationPppAprotein phosphorylationprotein-protein interactionprotein secretionPseudomonas aeruginosaTagFtype VI secretion system

Identifiers

PMID29599293
PMCPMC5995506
OpenAlexW2795101261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.