ArticleScience (New York, N.Y.)2018
Pulmonary neuroendocrine cells amplify allergic asthma responses.
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Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 246 papers.
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246citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
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Who cites it
246 citing papers in PubMed, 407 citations in OpenAlex.
- Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.Annals of medicine · 2026Review
- The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026Review
- Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling.JCI insight · 2026Article
- Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026Review
- Epithelial-immune interface in asthma: Mechanistic insights driving novel therapeutic strategies.Seminars in immunopathology · 2026Review
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- Group 2 innate lymphoid cells: Where are we 15 years out?The Journal of allergy and clinical immunology · 2026Review
- Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats.Particle and fibre toxicology · 2026Article
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Calcitonin Gene-Related Peptide (CGRP): Biology, Signaling, Pathophysiological Roles, and Therapeutic Applications.International journal of molecular sciences · 2026Review
- Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026Article
- CGRP reception potentiates anxiety in an influenza A derived immune engram.bioRxiv : the preprint server for biology · 2026Article
- Neuroimmune Dynamics in Diseases of the Arterial Wall: Mechanistic Foundations and Translational Prospects.Current atherosclerosis reports · 2026Review
- Overview of allergic disease: Pathogenesis of allergic inflammation - WAO White Book on Allergy 2026 - 2.1.The World Allergy Organization journal · 2026Review
- ILC2s and their immune checkpoints in the antitumor response.Journal for immunotherapy of cancer · 2026Review
- Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxidative stress in lung neurons.Science advances · 2026Article
- GDNF-RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation.FEBS letters · 2026Article
- Article
- Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development.Genomics, proteomics & bioinformatics · 2026Article
- Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
186 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 2 countries.
Pengfei SuiDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-8140-7050
Darin L WiesnerDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jinhao XuDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-4018-2825
Yan ZhangDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-1233-3219
Jinwoo LeeDepartment of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2991-4183
Steven Van DykenDepartment of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-9787-0883
Amber LashuaLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-4771-6172
Chuyue YuZhiyuan College, Shanghai JiaoTong University, Shanghai, China.ORCID 0000-0002-3286-3199
Bruce S KleinDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3212-1539
Richard M LocksleyDepartment of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-5468-6867
Gail DeutschDepartment of Laboratories, Seattle Children's Hospital, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-0571-0285
Xin SunDepartment of Pediatrics, University of California, San Diego, San Diego, CA 92093, USA. xinsun@ucsd.edu.ORCID 0000-0001-8387-4966
University of Wisconsin–Madison · USHoward Hughes Medical Institute · USSeattle Children's Hospital · USShanghai Jiao Tong University · CN
Funding
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2012 to 2023
$23.3MPROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4MRESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2MMolecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9MWisconsin Allergy Research Training (WISCART) ProgramT32AI007635 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2000 to 2026
$6.5MFoundational Mapping of the Neural Circuits that Control Intrinsic Lung FunctionOT2OD023857 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN, WANG, FAN · 2017 to 2020
$3.5MImpact of Early-in-life Disruption of Lung Development on Adult Lung Progenitor FunctionR01HL143256 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRINCE, LAWRENCE S, SUN, XIN · 2018 to 2021
$2.1MFGF Signaling in Lung Maturation and Response to InjuryR01HL113870 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SUN, XIN · 2012 to 2016
$2.1MCartilage and Smooth Muscle in Airway Tone and MicroenvironmentR01HL119946 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SUN, XIN · 2014 to 2017
$2.1MLung epithelial cell regulation of immunity to inhaled fungiR01AI130411 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2018 to 2021
$2.0MGenetic Basis of Normal and Pathological Alveologenesis in Lung DevelopmentR01HL142215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2018 to 2021
$2.0MRespiratory Deficiencies in Congenital Diaphragmatic HerniaR01HL122406 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SUN, XIN · 2015 to 2018
$1.8MNHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL113870NHLBI NIH HHS R01 HL119946NHLBI NIH HHS R01 HL122406NHLBI NIH HHS R01 HL142215NHLBI NIH HHS R01 HL143256NHLBI NIH HHS T32 HL007899NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI130411NIAID NIH HHS R37 AI035681NIAID NIH HHS T32 AI007635NIH HHS OT2 OD023857
Abstract
Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells whose function is poorly understood. Here we show that
Indexed as
AnimalsAsthmaBasic Helix-Loop-Helix ProteinsCalcitonin Gene-Related PeptideCytokinesDisease Models, AnimalEpithelial CellsFemalegamma-Aminobutyric AcidGoblet CellsHumansHyperplasiaLungMiceNeuroendocrine CellsAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsCalcitonin Gene-Related PeptideCytokinesgamma-Aminobutyric Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.