Evidence map›Paper›PMID 29599187›Full record

ArticleThe European respiratory journal2018

The

Jennifer L Goralski, Dan Wu, William R Thelin, Richard C Boucher, Brian Button

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Review
  6. Patient-managed interventions for adults with bronchiectasis: evidence, challenges and prospects.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
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  8. Article
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  10. Article
  11. Article
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  13. Article
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  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jennifer L GoralskiCystic Fibrosis Research and Treatment Center/Marsico Lung Institute, Chapel Hill, NC, USA.
Dan WuCystic Fibrosis Research and Treatment Center/Marsico Lung Institute, Chapel Hill, NC, USA.
William R ThelinParion Sciences, Durham, NC, USA.
Richard C BoucherCystic Fibrosis Research and Treatment Center/Marsico Lung Institute, Chapel Hill, NC, USA.
Brian ButtonCystic Fibrosis Research and Treatment Center/Marsico Lung Institute, Chapel Hill, NC, USA.
Lung Institute · USParion Sciences (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
The role of mucus and pulmonary surface interactions in lung defenseR01HL125280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUTTON, BRIAN M · 2015 to 2023
$3.1M
Novel Mucolytic AgentsR43HL112436 · NHLBI · PARION SCIENCES, INC. · PI BOYER, JOSE, THELIN, BILL · 2013 to 2013
$319k
NHLBI NIH HHS R01 HL125280NHLBI NIH HHS R43 HL112436NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

Inhaled hypertonic saline (HS) is an effective therapy for muco-obstructive lung diseases. However, the mechanism of action and principles pertinent to HS administration remain unclear.An

Indexed as

Cells, CulturedHumansInterleukin-8Membrane PotentialsModels, TheoreticalMucociliary ClearanceNebulizers and VaporizersOsmolar ConcentrationRespiratory MucosaSaline Solution, HypertonicInterleukin-8Saline Solution, Hypertonic

Identifiers

PMID29599187
PMCPMC6000726
OpenAlexW2795055822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.