Trial reportAJNR. American journal of neuroradiology2018
Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter: A Multicenter, Randomized, Controlled Clinical Trial (PARAT).
Trial report in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Single antiplatelet regimen in flow diverter treatment of cerebral aneurysms: The drug matters. A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Pooled it
- Sex Disparities in Intracranial Aneurysm Trial Participation: A Systematic Review and Meta-Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2026Pooled it
- Efficacy and safety of flow diverters for the treatment of intracranial aneurysms: a systematic review and meta-analysis.Frontiers in surgery · 2026Pooled it
- Safety and efficacy of tirofiban in the endovascular treatment of intracranial aneurysms: a systematic evaluation and meta-analysis.Neurosurgical review · 2025Pooled it
- A novel flow diverter device (Tubridge) for the treatment of intracranial aneurysms: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- The Safety and Efficacy of Flow Diversion versus Conventional Endovascular Treatment for Intracranial Aneurysms: A Meta-analysis of Real-world Cohort Studies from the Past 10 Years.AJNR. American journal of neuroradiology · 2022Pooled it
- Hemodynamic effect of coil packing density after tubridge flow diverter for anterior circulation small and medium-sized aneurysms.Scientific reports · 2026Article
- Application of machine learning algorithms to predict and assess factors related to internal carotid siphon aneurysm occlusion treated with flow diversion.Neuroradiology · 2026Article
- Half-dose ticagrelor versus clopidogrel dual antiplatelet therapy in flow diverter-treated intracranial aneurysms: analysis of platelet reactivity and perioperative safety outcomes.Acta neurochirurgica · 2026Article
- Flow Diversion vs. Coiling for Large and Giant Intracranial Aneurysms: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Comparison of flow diverters versus stent-assisted coiling in unruptured anterior circulation bifurcation aneurysms: a two-center, propensity score matched study.Neurosurgical review · 2026Article
- Comparison of coiling followed by staged-flow diversion and flow diversion-assisted coiling for intracranial very large and giant aneurysms of the internal carotid artery.Neurosurgical review · 2025Article
- Comparison of Tubridge and Pipeline Embolisation Devices in intracranial aneurysms: a multicentre, propensity-matching analysis on the patency of branch vessels.Neurosurgical review · 2025Article
- Efficacy and safety of flow diverters in basilar artery aneurysms: a single-center retrospective cohort study.Frontiers in neurology · 2025Article
- Conventional endovascular treatment and flow diverter for unruptured small- and medium-sized paraophthalmic segment aneurysms.Frontiers in neurology · 2025Article
- Tubridge flow-diverting stent for treatment of unruptured intracranial complex aneurysms.Frontiers in neurology · 2025Article
- Article
- Flow Diversion for Cerebral Aneurysms: A Decade-Long Experience with Improved Outcomes and Predictors of Success.Brain sciences · 2024Article
- Study the local metabolic changes of aneurysms through microcatheter sampling.Scientific reports · 2024Article
- Image Follow-Up After Flow Diverter Treatment Using Only Ultra-High Resolution CT Angiography with Model-Based Iterative Reconstruction: A Case Report.Yonago acta medica · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAlthough flow diverters have been reported with favorable clinical and angiographic outcomes in various literatures, randomized trials determining their true effectiveness and safety are still in lack. The Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter (PARAT) trial was designed to evaluate the safety and efficacy of the Tubridge flow diverter in the treatment of large or giant aneurysms in comparison with Enterprise stent-assisted coiling. MATERIALS AND
methodsThis prospective, multicenter, randomized trial was conducted at 12 hospitals throughout China. Enrolled adults with unruptured large/giant intracranial aneurysms were randomly assigned (1:1) to receive either Enterprise stent-assisted coiling or Tubridge flow diverter implantation. The primary end point was complete occlusion at 6-month follow-up, while secondary end points included technical success, mortality, target vessel-related stroke, aneurysm bleeding, in-stent stenosis, parent artery occlusion, and the frequency of all adverse events.
resultsAmong 185 enrolled subjects, 41 withdrew before procedure initiation. Overall, 82 subjects underwent Tubridge implantation, and 62 subjects were primarily treated with stent-assisted coiling. The results of 6-month follow-up imaging included complete occlusion rates of 75.34% versus 24.53% for the Tubridge and stent-assisted coiling groups, respectively, with a calculated common odds ratio of 9.4 (95% confidence interval, 4.14-21.38;
conclusionsThis trial showed an obviously higher rate of large and giant aneurysm obliteration with the Tubridge FD over Enterprise stent-assisted coiling. However, this higher obliteration rate came at the cost of a nonsignificantly higher rate of complications. Investigational site comparisons suggested that a learning curve for flow-diverter implantation should be recognized and factored into trial designs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.