Evidence map›Paper›PMID 29599133›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo.

Kristin L Bowden, Joshua A Dubland, Teddy Chan, You-Hai Xu, Gregory A Grabowski, Hong Du, Gordon A Francis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Recent insights into lysosomal acid lipase deficiency.Trends in molecular medicine · 2023
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Lysosomal Acid Lipase in Lipid Metabolism and Beyond.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kristin L BowdenFrom the Department of Medicine, Centre for Heart Lung Innovation, Institute for Heart + Lung Health, Providence Health Care Research Institute at St. Paul's Hospital, University of British Columbia, Vancouver, Canada (K.L.B., J.A.D., T.C., G.A.F.).
Joshua A DublandFrom the Department of Medicine, Centre for Heart Lung Innovation, Institute for Heart + Lung Health, Providence Health Care Research Institute at St. Paul's Hospital, University of British Columbia, Vancouver, Canada (K.L.B., J.A.D., T.C., G.A.F.).
Teddy ChanFrom the Department of Medicine, Centre for Heart Lung Innovation, Institute for Heart + Lung Health, Providence Health Care Research Institute at St. Paul's Hospital, University of British Columbia, Vancouver, Canada (K.L.B., J.A.D., T.C., G.A.F.).
You-Hai XuDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, OH (Y.-H.X., G.A.G.).
Gregory A GrabowskiFrom the Department of Medicine, Centre for Heart Lung Innovation, Institute for Heart + Lung Health, Providence Health Care Research Institute at St. Paul's Hospital, University of British Columbia, Vancouver, Canada (K.L.B., J.A.D., T.C., G.A.F.).
Hong DuDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis (H.D.).
Gordon A FrancisFrom the Department of Medicine, Centre for Heart Lung Innovation, Institute for Heart + Lung Health, Providence Health Care Research Institute at St. Paul's Hospital, University of British Columbia, Vancouver, Canada (K.L.B., J.A.D., T.C., G.A.F.) gordon.francis@hli.ubc.ca.
Cincinnati Children's Hospital Medical Center · USUniversity of British Columbia · CASt. Paul's Hospital · CASt. Paul's Hospital · CA

Funding

Pathophysiology of PPARgamma in the lungR01HL087001 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DU, HONG · 2008 to 2012
$1.9M
CIHR MOP 79532CIHR PJT 148883NHLBI NIH HHS R01 HL087001
6 · The paper itself

Abstract

objectiveTo explore the role of LAL (lysosomal acid lipase) in macrophage cholesterol efflux and whole-body reverse cholesterol transport. APPROACH AND

resultsImmortalized peritoneal macrophages from lal

conclusionsThese results indicate a critical role for LAL in promoting both macrophage and whole-body reverse cholesterol transport and the ability of supplemental LAL to be taken up and correct reverse cholesterol transport in vivo.

Indexed as

AnimalsApolipoprotein A-IATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8Biological TransportCell LineCholesterolFecesLipoproteinsLiverMacrophages, PeritonealMice, 129 StrainMice, KnockoutSterol EsteraseAbca1 protein, mouseABCG1 protein, mouseABCG5 protein, mouseABCG8 protein, mouseAPOA1 protein, humanApolipoprotein A-IATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8CholesterolLIPA protein, humanLipoproteinslysosomal acid lipase, mouseSterol Esteraseanimalscholesterolmacrophagesmicesterol esterase

Identifiers

PMID29599133
PMCPMC5920716
OpenAlexW2795109521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.