Trial reportVaccine2018
Cancer-salient messaging for Human Papillomavirus vaccine uptake: A randomized controlled trial.
Trial report in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03002324 (Tailoring of Vaccine-Focused Messages), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tailoring of Vaccine-Focused Messages: Moral Foundations and Disease Salience - Part 2
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Tailoring educational interventions targeting parental vaccine hesitancy: a systematic review of quantitative studies.Frontiers in public health · 2026Pooled it
- A systematic review of interventions to promote HPV vaccination globally.BMC public health · 2023Pooled it
- Nudging toward vaccination: a systematic review.BMJ global health · 2021Pooled it
- How to make effective HPV vaccine recommendations starting at age 9.Human vaccines & immunotherapeutics · 2023Article
- Factors associated with HPV vaccine acceptability and hesitancy among Black mothers with young daughters in the United States.Frontiers in public health · 2023Article
- The effect of education based on the theory of planned behavior on the intention of vaccination against human papillomavirus in female students: A controlled educational trial.Journal of education and health promotion · 2022Article
- The interdependent roles of the psychosocial predictors of human papillomavirus vaccination among Christian parents of unvaccinated adolescents.Human vaccines & immunotherapeutics · 2021Article
- Association of cognitive biases with human papillomavirus vaccine hesitancy: a cross-sectional study.Human vaccines & immunotherapeutics · 2020Article
- A Tale of Two Diverse Qualtrics Samples: Information for Online Survey Researchers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
BACKGROUND AND
objectivesVaccination with Human Papillomavirus (HPV) vaccine is recommended for 11-12 years-old, but uptake is suboptimal. Current messaging focuses on HPV infection transmission and prevention. Parents and providers are often uncomfortable discussing sexual practices of adolescents, contributing to the delay/refusal of vaccine. We created a cervical cancer-salient message encouraging HPV vaccination, emphasizing disease salience and disease threat, while promoting self-efficacy. We hypothesized this message would have greater effects on vaccine confidence and intent to vaccinate compared to Centers for Disease Control and Prevention (CDC) and non-vaccine control messages.
methodsA 3-arm randomized trial was conducted. Parents of girls aged 9-17 were eligible for the study. We measured participants' vaccine confidence and intent to vaccinate at baseline and post intervention message. Recruitment and surveys were administered online through Amazon Mechanical Turk.
results762 participants completed both surveys. We saw modest increases in vaccine confidence when comparing cervical cancer arm and control arm, and CDC arm and control arm; estimates were not statistically significant. The odds of reporting intent to vaccinate among the cervical cancer message arm were 1.13 times the odds of reporting intent to vaccinate in the control arm (95% CI: 0.30. 4.29). Intent to vaccinate was also not statistically significantly different between CDC message arm and control arm (OR = 1.25, 95%CI: 0.66, 2.37).
conclusionNeither message had effect on intent to vaccinate, highlighting need for research to identify successful messaging strategies for HPV. Exploratory analyses suggest among parents with 'Low' vaccine confidence at baseline, the cervical cancer framed message may be more effective in changing intention than the CDC message or non-vaccine control. Future work should target groups with 'Low' or 'Medium' vaccine confidence at baseline - they may be more amenable to change, and more receptive to disease-salient messaging. CLINICAL
trial registrationClinicaltrials.gov, Reference #: NCT03002324.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.